**5.3.84 Trypan blue and trypan red**

The antimicrobial agents trypan blue and trypan red did not show a beneficial effect in ALS patients (Montanari & Pessina, 1955; Schwob & Bonduelle, 1952).

### **5.3.85 Vascular endothelial growth factor (VEGF, sNN0029)**

VEGF is a neuroprotectice and angiogenic growth factor (Maurer et al., 2008). It is currently tested in a phase I/II clinical trial (NCT00800501) for safety and tolerability. Of note, VEGF must be administered into the CSF.
