**5.3.39 ISIS 333611 (ISIS-SOD1Rx)**

ISIS 333611 is an antisense oligonucleotide inhibitor of Cu/Zn superoxide dismutase (SOD1) (Smith et al., 2006). Currently, a phase I (NCT01041222) investigates the safety, tolerability, and activity familial ALS caused by SOD1 gene mutations.

### **5.3.40 Isoprinosine**

The antiviral drug isoprinosine did not show a benefit in ALS patients (Fareed & Tyler, 1971; Percy et al., 1971).
