**2. ALS and immunity**

In the last decades, increasing numbers of experimental and clinical observations have reported inflammatory reactions in ALS tissues which indicate the involvement of both the innate and adaptive immune responses (Fig. 1) (McGeer & McGeer, 2006; Moisse & Strong, 2006; Sta et al., 2011; Weydt et al., 2002).

So far it is not clear how immune system is involved in ALS disease, whether the adaptive or innate immunity has a major role and whether immunity is part of damaging or neuroprotective response to the pathological process.

Fig. 1. Innate and adaptive immunity.
