**7. Abbreviations**

ALS, amyotrophic lateral sclerosis ALSFRS, ALS functional rating scale ALSSS, ALS severity scale CNS, central nervous system FTD, Fronto-Temporal Dementia LMN, lower motor neuron MND, motor neuron disease PBP, progressive bulbar palsy PLS, primary lateral sclerosis PMA, progressive muscular atrophy ROS, Reactive oxygen species SOD1, [Zn, Cu] Superoxide dismutase type 1 UMN, upper motor neuron
