**5. Conclusions**

Despite the ever-growing reductionist record on cell biology of constitutive parts of pancreas (exocrine, ductal and endocrine), whole organ integrative physiology detailing organ development, blood and lymphatic vascularization, innervation and direct links to pancreatic role in intestinal digestion, is rarely part of a single review. The present chapter goes even further and gives examples where this knowledge can provide a basis to understand etiopathophysiology of most common pancreatic diseases, including malignancy. We created a series of images to merge the different cell biological, anatomical and physiological layers to explain modern pancreas function and possible causes for dysfunction.
