**Genetic Aspect of Headache Genetic Aspect of Headache**

Tuba Gökdoğan Edgünlü and Sevim Karakas Çelik Çelik

Additional information is available at the end of the chapter Additional information is available at the end of the chapter

Tuba Gökdoğan Edgünlü and Sevim Karakas

http://dx.doi.org/10.5772/66852

#### **Abstract**

Headache is a multifactorial disease and the genetic basis is not clear yet. We review recent findings about molecular basis of subtypes of headache. The fundamentals of molecular genetics and the recent advances in this area are important for clinicians to understand the pathogenesis of the disorder. Recent studies provide a foundation for critical appraisal of the literature, unprecedented insights and reveal promising treat‐ ment targets for future drug development. This chapter provides an overview of molecu‐ lar genetics, epigenetic and genome‐wide association studies on headache. In summary, we try to explain the state‐of‐the‐art molecular basis of headache and the possible future direction in this field of research studies. According to recent studies the main types of are evaluative, exploratory about molecular basis of headache. In recent years, new studies have been designed to provide an update and understanding of the modern day genetics, the advances in genetic research and methods and a basis for understanding the strategy by which advances in molecular genetics can be applied for understanding complex polygenetic diseases such as migraine.

**Keywords:** headache, genetic, epigenetic, cluster type headache, tension type headache, migraine
