**Biopolymer in Gene Delivery**

**Biopolymer in Gene Delivery**

#### Sakthivel Lakshmana Prabu and Kandasamy Ruckmani Kandasamy Ruckmani Additional information is available at the end of the chapter

Sakthivel Lakshmana Prabu and

Additional information is available at the end of the chapter

http://dx.doi.org/10.5772/65694

#### **Abstract**

[91] Helmke A, Hoffmeister D, Mertens N, Emmert S, Schuette J and Vioel W. The acidification of lipid film surfaces by non-thermal DBD at atmospheric pressure in air. New

[92] Babaeva N Y, Ning N, Graves D B and Kushner M J. Ion activation energy delivered to wounds by atmospheric pressure dielectric-barrier discharges: sputtering of lipid-like surfaces. J. Phys. D: Appl. Phys. 2012;45:115203. DOI: 10.1088/0022-3727/45/11/115203

[93] Martin G T, Pliquett U F and Weaver J C. Theoretical analysis of localized heating in human skin subjected to high voltage pulses. Bioelectrochemistry. 2002;57:55–64. DOI:

[94] Yen W F, Basri M, Ahmad M and Ismail M. Formulation and evaluation of galantamine gel as drug reservoir in transdermal patch delivery system. Sci. World J. 2015;2015:

J. Phys. 2009;11:115025. DOI: 10.1088/1367-2630/11/11/115025

10.1016/S1567-5394(01)00176-1

136 Advanced Technology for Delivering Therapeutics

495271. DOI: 10.1155/2015/495271

Nowadays, biopolymers, a class of biomaterials, represent frontier area in the drug delivery systems. Drug release from nano- and microparticles is a complex process, which involves several steps. Uptake of nanoparticle in the intracellular is affected by numerous factors. Recently, gene delivery has been considered one of the promising approaches for the treatment of various diseases acquired genetically in human being. The use of biopolymers as nanoparticles in gene delivery can potentially avoid many of the safety concerns in the gene delivery system. In gene delivery, the genetic materials such as DNA plasmids, RNA and siRNA are either encapsulated inside or conjugated to the nanoparticles, which protects the genetic materials until the drug reaches its target site. Treatment of the diseases is based on the effective delivery of the genetic materials into specific cells that are responsible for disease development. Various properties such as particle size, surface charge, morphology of the surface and release rate of the loaded molecules are the important parameters in the gene delivery system. In this chapter, various biopolymers (cationic polymers) and inorganic non-viral-delivery vectors used in gene delivery used as therapeutic agents are discussed.

**Keywords:** gene delivery, polymers, biopolymers, delivery system, therapeutic effect
