**8. Conclusion**

Nanotechnology is a science adapted in various research areas specifically in the drugdelivery system. At present, gene delivery system includes viral-based, non-viral-based and combined hybrid systems, which are widely used for the treatment of various diseases. To provide the desired concentration of the drug in the target site and therapeutic effect is critical of the drug-delivery system. Biopolymer is a biomaterial that has been utilized extensively for formulating genetic material into a nanoparticle either embedded or encapsulated within the polymeric matrix. Despite various biopolymers, choosing a suitable biopolymer, nanoparticle preparation procedure with desired properties can achieve the bio-distribution and effective delivery of the genetic material into the target site and regulate the damaged genes to produce the required proteins.
