**7. Fungal CNE**

Per the European guidelines, for *Aspergillus* infections, voriconazole is the drug of choice, and some experts recommend the addition of an echinocandin or amphotericin B. Surgery is generally required, and prolonged suppressive therapy is recommended. For *H. capsulatum*, surgical management followed by 6 weeks of amphotericin B and additional suppressive oral itraconazole is recommended. Most agents have poor activity against other mold species like *Trichosporon* spp. The mainstay of therapy is surgical.
