**5. Future outlook and conclusions**

Dementia is a global public health challenge that requires urgent action to discover underlying molecular mechanism and to develop cure. Classical biological methods involving analyses of one or several genes have been adopted in the study of the pathogenesis of neurodegenerative disorders. However, it has become clear that neurodegenerative disorders exhibit complex interactions involving wide range of proteins. Proteomics technologies have ushered in a new era in the fields of clinical research by enabling us in identifying and quantifying diseaserelated protein profiles. Unbiased, global, discovery-driven approaches such as proteomics are well suited to uncover the complex pathology of human proteinopathies such as dementia. Therefore, in this chapter, we exploited state-of-the-art quantitative proteomic profiling of brain proteome, and discussed recent developments in neuroproteomics including DPMs, its impact on protein aggregation that alters protein function and causes deposition, which are key features of dementia and neurodegenerative disorders. To further understand the pathology in depth, along with discovery proteomic approach, targeted proteomics need to be applied to develop cure. In addition, commitments are needed to generate strategies, government policies, programs, and research funding for neurodegenerative diseases. However, obtaining well-characterized clinical samples of specific brain areas remains a major limitation.
