**1. Introduction**

Alzheimer's disease (AD) is the most commonly diagnosed dementia in aging individuals older than 65 years [1]. The typical clinical symptoms include progressive cognitive decline and memory impairments. The hallmarks of the disease include aggregation of insoluble Aβ peptides and hyper-phosphorylated tau, resulting in the formation of amyloid plaques and neurofibril‐ lary tangles (NFT), respectively, in the brain. Several studies including sequencing, metaanalysis, and genome-wide association studies have highlighted more than 20 AD-associated loci, as well as several molecular pathways altered in AD pathology.

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