Contents

#### **Preface XIII**


Chapter 8 **Beta Amyloid Peptides: Extracellular and Intracellular**

Chapter 9 **Alzheimer's Disease: From Animal Models to the Human**

Quiroz-Mercado

**Syndrome 191**

**Section 2 Clinical Section 249**

Chapter 10 **Risk Factors for Alzheimer's Disease 225**

Alyssa A. Brewer and Brian Barton

Sarah K. Woody and Liqin Zhao

**Diagnosis and Follow‐up 379**

Chapter 11 **Normal Aging and Dementia 251**

**a New Role 311**

A. Quintanilla

and José M. Ramírez

**and Nursing 427**

Ogunlade

Dongming Cai and Farida El Gaamouch

**Mechanisms of Clearance in Alzheimer's Disease 169** Luis F. Hernández-Zimbrón, Elisa Gorostieta-Salas, Mei-Li Díaz-Hung, Roxanna Pérez-Garmendia, Gohar Gevorkian and Hugo

Erika Orta‐Salazar, Isaac Vargas‐Rodríguez, Susana A Castro‐ Chavira, Alfredo I. Feria‐Velasco and Sofía Díaz‐Cintra

Michał Prendecki, Jolanta Florczak-Wyspianska, Marta Kowalska, Margarita Lianeri, Wojciech Kozubski and Jolanta Dorszewska

Chapter 12 **Changes in Visual Cortex in Healthy Aging and Dementia 273**

Chapter 13 **Clusterin (APOJ) in Alzheimer's Disease: An Old Molecule with**

Chapter 14 **New Targets for Diagnosis and Treatment Against Alzheimer's Disease: The Mitochondrial Approach 349**

Chapter 15 **The Impact of the Eye in Dementia: The Eye and its Role in**

Chapter 16 **Caring for Individuals with Dementia on a Continuum: An Interdisciplinary Approach Between Music Therapy**

María José Pérez, Claudia Jara, Ernesto Muñoz‐Urrutia and Rodrigo

Elena Salobrar‐García, Ana I. Ramírez, Rosa de Hoz, Pilar Rojas, Juan J. Salazar, Blanca Rojas, Raquel Yubero, Pedro Gil, Alberto Triviño

Kendra Ray, Ayelet Dassa, Jan Maier, Renita Davis and Olayinka


Erika Orta‐Salazar, Isaac Vargas‐Rodríguez, Susana A Castro‐ Chavira, Alfredo I. Feria‐Velasco and Sofía Díaz‐Cintra

Contents **VII**

	- **Section 2 Clinical Section 249**

Chapter 17 **Behavior and Emotion in Dementia 449**

**Dementia 477**

**Dementia 493**

**SADEM Study 515**

**Treatment 529**

Teresa Mayordomo Rodríguez, Alicia Sales Galán, Rita Redondo

Grazia D'Onofrio, Daniele Sancarlo, Davide Seripa, Francesco Ricciardi, Francesco Giuliani, Francesco Panza and Antonio Greco

**Development and Evaluation of a Multilingual Information Resource for Family Caregivers of People Living with**

Robyn Gillespie, Pippa Burns, Lindsey Harrison, Amanda Baker, Khin

Juárez‐Cedillo Teresa, Hsiung Ging‐Yuek, Sepehry A. Amir, Beattie

Flores, Marta Torres Jordán and Javier Bendicho Montes

Chapter 18 **Non-Pharmacological Approaches in the Treatment of**

Chapter 19 **Medication Management for People Living with Dementia:**

Chapter 20 **Diabetes Mellitus and Depression as Risk Factors for Dementia:**

B. Lynn, Jacova Claudia and Escobedo de la Peña Jorge

Chapter 21 **Idiopathic Normal Pressure Hydrocephalus: An Overview of Pathophysiology, Clinical Features, Diagnosis and**

Win, Victoria Traynor and Judy Mullan

Rubesh Gooriah and Ashok Raman

Chapter 17 **Behavior and Emotion in Dementia 449** Teresa Mayordomo Rodríguez, Alicia Sales Galán, Rita Redondo Flores, Marta Torres Jordán and Javier Bendicho Montes

Chapter 8 **Beta Amyloid Peptides: Extracellular and Intracellular**

Chapter 9 **Alzheimer's Disease: From Animal Models to the Human**

Quiroz-Mercado

**VI** Contents

Chapter 8 **Beta Amyloid Peptides: Extracellular and Intracellular**

Chapter 9 **Alzheimer's Disease: From Animal Models to the Human**

Quiroz-Mercado

**Syndrome 191**

**Section 2 Clinical Section 249**

Chapter 10 **Risk Factors for Alzheimer's Disease 225**

Alyssa A. Brewer and Brian Barton

Sarah K. Woody and Liqin Zhao

**Diagnosis and Follow‐up 379**

Chapter 11 **Normal Aging and Dementia 251**

**a New Role 311**

A. Quintanilla

and José M. Ramírez

**and Nursing 427**

Ogunlade

Dongming Cai and Farida El Gaamouch

**Mechanisms of Clearance in Alzheimer's Disease 169** Luis F. Hernández-Zimbrón, Elisa Gorostieta-Salas, Mei-Li Díaz-Hung, Roxanna Pérez-Garmendia, Gohar Gevorkian and Hugo

Erika Orta‐Salazar, Isaac Vargas‐Rodríguez, Susana A Castro‐ Chavira, Alfredo I. Feria‐Velasco and Sofía Díaz‐Cintra

Michał Prendecki, Jolanta Florczak-Wyspianska, Marta Kowalska, Margarita Lianeri, Wojciech Kozubski and Jolanta Dorszewska

Chapter 12 **Changes in Visual Cortex in Healthy Aging and Dementia 273**

Chapter 13 **Clusterin (APOJ) in Alzheimer's Disease: An Old Molecule with**

Chapter 14 **New Targets for Diagnosis and Treatment Against Alzheimer's Disease: The Mitochondrial Approach 349**

Chapter 15 **The Impact of the Eye in Dementia: The Eye and its Role in**

Chapter 16 **Caring for Individuals with Dementia on a Continuum: An Interdisciplinary Approach Between Music Therapy**

María José Pérez, Claudia Jara, Ernesto Muñoz‐Urrutia and Rodrigo

Elena Salobrar‐García, Ana I. Ramírez, Rosa de Hoz, Pilar Rojas, Juan J. Salazar, Blanca Rojas, Raquel Yubero, Pedro Gil, Alberto Triviño

Kendra Ray, Ayelet Dassa, Jan Maier, Renita Davis and Olayinka

**Syndrome 191**

**Section 2 Clinical Section 249**

Chapter 10 **Risk Factors for Alzheimer's Disease 225**

Alyssa A. Brewer and Brian Barton

Sarah K. Woody and Liqin Zhao

**Diagnosis and Follow‐up 379**

Chapter 11 **Normal Aging and Dementia 251**

**a New Role 311**

A. Quintanilla

and José M. Ramírez

**and Nursing 427**

Ogunlade

Dongming Cai and Farida El Gaamouch

**Mechanisms of Clearance in Alzheimer's Disease 169** Luis F. Hernández-Zimbrón, Elisa Gorostieta-Salas, Mei-Li Díaz-Hung, Roxanna Pérez-Garmendia, Gohar Gevorkian and Hugo

Contents **VII**

**VIII** Contents

Erika Orta‐Salazar, Isaac Vargas‐Rodríguez, Susana A Castro‐ Chavira, Alfredo I. Feria‐Velasco and Sofía Díaz‐Cintra

Michał Prendecki, Jolanta Florczak-Wyspianska, Marta Kowalska, Margarita Lianeri, Wojciech Kozubski and Jolanta Dorszewska

Chapter 12 **Changes in Visual Cortex in Healthy Aging and Dementia 273**

Chapter 13 **Clusterin (APOJ) in Alzheimer's Disease: An Old Molecule with**

Chapter 14 **New Targets for Diagnosis and Treatment Against Alzheimer's Disease: The Mitochondrial Approach 349**

Chapter 15 **The Impact of the Eye in Dementia: The Eye and its Role in**

Chapter 16 **Caring for Individuals with Dementia on a Continuum: An Interdisciplinary Approach Between Music Therapy**

María José Pérez, Claudia Jara, Ernesto Muñoz‐Urrutia and Rodrigo

Elena Salobrar‐García, Ana I. Ramírez, Rosa de Hoz, Pilar Rojas, Juan J. Salazar, Blanca Rojas, Raquel Yubero, Pedro Gil, Alberto Triviño

Kendra Ray, Ayelet Dassa, Jan Maier, Renita Davis and Olayinka

Chapter 18 **Non-Pharmacological Approaches in the Treatment of Dementia 477** Grazia D'Onofrio, Daniele Sancarlo, Davide Seripa, Francesco

Ricciardi, Francesco Giuliani, Francesco Panza and Antonio Greco

Chapter 19 **Medication Management for People Living with Dementia: Development and Evaluation of a Multilingual Information Resource for Family Caregivers of People Living with Dementia 493**

> Robyn Gillespie, Pippa Burns, Lindsey Harrison, Amanda Baker, Khin Win, Victoria Traynor and Judy Mullan

#### Chapter 20 **Diabetes Mellitus and Depression as Risk Factors for Dementia: SADEM Study 515**

Juárez‐Cedillo Teresa, Hsiung Ging‐Yuek, Sepehry A. Amir, Beattie B. Lynn, Jacova Claudia and Escobedo de la Peña Jorge

#### Chapter 21 **Idiopathic Normal Pressure Hydrocephalus: An Overview of Pathophysiology, Clinical Features, Diagnosis and Treatment 529**

Rubesh Gooriah and Ashok Raman
