**Acknowledgements**

This work was funded by grants from Instituto de Salud Carlos III, through PI10/00160 and PI12/02839 and partially supported by F.E.D.E.R., from PIP CONICET 11220150100133CO and Mutua Madrileña. A.S.-G. is the recipient of a postdoctoral fellow from Mutua Madrileña.
