**5. Conclusion**

TWO2 therapy is practical, effective and valuable in managing RVU without the risks associ‐ ated with full‐body hyperbaric chambers. TWO2 therapy requires no further specialist skills by the primary care physician or local tissue viability nurse. It is therefore readily available for application under most circumstances, even for domiciliary use. The treatment has an extremely low risk of systemic complications when compared to HBO, and single‐use devices greatly reduce the possibility of secondary infections.

TWO2 slashes the time needed for RVU healing and is successful in pain alleviation, MRSA elimination and management. Utilising diffused oxygen raises the capillary partial Po2 levels at the wound site, stimulating epithelialisation and granulation of new healthy tissue. TWO2 therapy radically degrades recurrence rates. Taking the social and individual aspects of chronic venous ulceration into account, the use of TWO2 can provide an overwhelmingly improved quality of life for long‐time sufferers of this debilitating disease.
