**The Physiological Roles of Leptin in Skin Wound Healing The Physiological Roles of Leptin in Skin Wound Healing**

Reiko Tokuyama-Toda and Kazuhito Satomura

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Reiko Tokuyama-Toda and Kazuhito Satomura Additional information is available at the end of the chapter

Additional information is available at the end of the chapter

http://dx.doi.org/10.5772/63368

### **Abstract**

Leptin, a 16 kDa circulating anti-obesity hormone, has many physiological properties such as body weight homeostasis, lipid metabolism, hematopoiesis, thermogenesis, ovarian function, bone formation, and angiogenesis. Interestingly, a certain study showed that skin wound healing delayed in leptin deficient *ob/ob* mice. However, little has been known about the physiological role of leptin in skin wound healing. In this chapter, we introduce whether local and single-dose administration of leptin exerted a promotive influence on the skin wound healing. Immunohistochemical analysis revealed that leptin receptor was expressed in mouse epidermal cells. In addition, topical administration of leptin promoted the healing of chemical burn wounds created on the back skin of mice without any side effects. Then, the mechanisms of the promotive effect of leptin on the wound healing of the skin were demonstrated immunohistochemical and biological analysis; namely, leptin stimulated angiogenesis in the connective tissue beneath the wounded area and the cell proliferation, differentiation/ function, and migration of human epidermal keratinocytes. These findings revealed the possible and promising usefulness of leptin as a new wound-healing promoting agent.

**Keywords:** leptin, skin, wound healing, new promoting agent, local administration
