**7. CO2 laser and wound healing**

There are some anecdotal reports of CO2 laser and wound healing. In an interesting case series two pediatric patients with chronic wounds within scars showed rapid healing with a single‐ pass treatment by fractionated carbon dioxide (CO2) laser [46]. In another case series done by Phillips et al., CO2 laser was used in the treatment of posttraumatic slow healing wounds in three elderly patients. In their report each wound was healed by 60% or greater within 3 weeks [47]. In an interesting article reepithelialization and accelerated wound healing within 4 weeks was reported in one recessive dystrophic epidermolysis bullosa (RDEB) patient with CO2 laser without blistering or other adverse effects [48]. Although there are no considerable reports of the efficacy of fractional carbon dioxide laser on wound healing, it seems that it has a promising effect on chronic wound without remarkable complications.

### **7.1. Contraindication**

Isotretinoin use within the previous 6 months, active cutaneous bacterial or viral infection in the area to be treated, history of keloid formation or hypertrophic scarring, ongoing ultraviolet exposure, prior radiation therapy to treatment area, collagen vascular disease, chemical peel, and dermabrasion [49].
