**Author details**

Implanted devices or hormones.

368 Wound Healing - New insights into Ancient Challenges

**7. CO2 laser and wound healing**

**7.1. Contraindication**

and dermabrasion [49].

**8. Conclusion**

effect on chronic wound without remarkable complications.

growth.

cancer.

*6.1.2. Relative*

Epiphysis: Open growth plates could potentially be damaged by shock wave either by using settings that create more growth and close them too quickly or by using settings that delay

Genitals; pregnancy; clotting disorders/anticoagulants; joint replacements, certain settings have been used to loosen previously implanted joints ready for a new implant; infection; and

Corticosteroid injection: Generally people recommend waiting 1 month before application [45].

There are some anecdotal reports of CO2 laser and wound healing. In an interesting case series two pediatric patients with chronic wounds within scars showed rapid healing with a single‐ pass treatment by fractionated carbon dioxide (CO2) laser [46]. In another case series done by Phillips et al., CO2 laser was used in the treatment of posttraumatic slow healing wounds in three elderly patients. In their report each wound was healed by 60% or greater within 3 weeks [47]. In an interesting article reepithelialization and accelerated wound healing within 4 weeks was reported in one recessive dystrophic epidermolysis bullosa (RDEB) patient with CO2 laser without blistering or other adverse effects [48]. Although there are no considerable reports of the efficacy of fractional carbon dioxide laser on wound healing, it seems that it has a promising

Isotretinoin use within the previous 6 months, active cutaneous bacterial or viral infection in the area to be treated, history of keloid formation or hypertrophic scarring, ongoing ultraviolet exposure, prior radiation therapy to treatment area, collagen vascular disease, chemical peel,

Managing chronic and refractory wounds represents a significant dilemma that physicians are facing and needs invention of new treatment modalities. Wide ranges of the above physical modalities have been introduced and used in wound‐healing treatment with different efficacies, but most of them, to some extent, are strange for patients and physicians. Although additional clinical studies must be performed in order to find out the best modalities and the best parameters of wavelength, dosage, and methodology, and especially appropriate treat‐ Amir Feily1\*, Fatemeh Moeineddin1 and Shadi Mehraban2

