**5. Methods used for pinpointing herbal materials and natural products with wound healing property**

Electronic databases such as PubMed, Scifinder® and Google Scholar were used to search medicinal plants that have been evaluated for wound healing. All filtered articles were appraised to determine whether they contain any validated *in vitro* or *in vivo* wound model. Primary search results were independently screened by two investigators. Included articles were reviewed concerning plant botanical names, part of plants used in the respective study and type of plant extracts, active constituents or compounds and wound models used (*in vivo* or *in vitro*) or standardized clinical trials with clearly demonstrated wound healing activity in the models used. Consideration was given to the significant differences between test group and control group with respect to wound contraction, wound tensile strength, period of epithelialization, neovascularization, collagenation, keratinization and fibrosis. In case of clinical studies, the respective design, number of patients, interventions, duration of treatment, and data related to the efficacy and tolerability of the patients to treatment were also monitored.
