**2.5. Another important contribution to the study of neoangiogenesis and biomaterials prefabrication**

Our group also developed a collaboration with the group from Padriciano, International Center for Genetic Engineering and Biology, United Nations, to study a model of prefabricated flap in the groin of adult rats creating an artero‐venus loop that was included into a dermal regenerative template; this new regeneration chamber was then injected with different viral vectors (AAV 156) encoding for the production of VEGF. Results were remarkable, demon‐ strating enhancement of neoangiogenesis and neovasculogenesis and the utility of this novel model of regeneration chamber that could act as a bioreactor and stimulate healing and even repair poor vascularized tissues [14, 15].
