**The Selection Strategy for Circulating Tumor Cells (CTCs) Isolation and Enumeration: Technical Features, Methods, and Clinical Applications**

Jason Chia‐Hsun Hsieh and Tyler Ming‐Hsien Wu

Additional information is available at the end of the chapter

http://dx.doi.org/10.5772/64812

#### **Abstract**

The key aim of the proposed chapter is to provide readers a brief description for the most important parts of the field of circulating tumor cells (CTCs): the core techni‐ ques, including negative and positive selection‐based CTC isolation, and the differen‐ ces between them. Most importantly, we will also review the clinical applications and important findings in clinical trials. The evidence‐based review will not only help clinicians use CTCs to predict recurrence and foresee the disease‐related outcomes but also to inspire the researchers in this field to conduct further investigations.

**Keywords:** circulating tumor cells, negative selection, cancer, stem cell, liquid biopsy
