**5. Chemotherapeutic agent-loaded bone cement**

Beyond the injection of bone cement only, there is growing interest on therapeutic effects on mixture of bone cement and chemotherapeutic agents. Many studies suggested that antineo‐ plastic agent–loaded bone cement not only prevents tumor recurrences with better local tumor control but also decreases the number of distant metastases [11].

According to the literature, percutaneous injection with a mixture of gemcitabine and PMMA bone cement was applied to two patients of femoral neck metastasis from lung cancer [7]. In vitro test reported that the antineoplastic agents, such as cisplatin laden bone cement, hinder

the growth of giant tumor cells, colon cancer cells, lung cancer cells, and breast cancer cells [11]. But further studies are needed to investigate efficacy of the chemotherapeutic agents incor‐ porated into bone cement.
