**7.1. Pharmacological prevention of neurocognitive impairment**

Neuroprotective agents may be used to protect healthy tissue against neuronal cell death or degeneration caused by the treatment of brain tumor.

Lithium can be used to protect progenitor cells in the hippocampus through inhibition of radiation-induced apoptosis and induction of the DNA repair, and the tumor cells not included in this protection process. A study conducted by Yang et al. [117] found that neurocognitive performance in mice was improved after receiving lithium concomitant with RT, anthor neuroprotective drug; fenofibrate which prevents activation of microglia. Administration of fenofibrate during whole-brain RT prevents effects on hippocampal neurogenesis in mice, as it enhances survival of newborn neurons in the dentate gyrus [118].
