**13. Conclusion**

LITT is a stereotactic minimally invasive technique that involves ablation of pathological tissue using laser energy. This technique has shown promising results in a variety of neuro-onco‐ logical conditions such as recurrent GBM, upfront deep-seated GBM, recurrent metastasis following SRS, radiation necrosis and cancer-related pain. LITT was approved by FDA in 2009 for unlimited intracranial usage. Minimally invasive nature of the therapy coupled with realtime monitoring of thermal ablation are distinct advantages of LITT over traditional surgical approaches, especially for deep-seated tumors in patients with significant co-morbidities. Currently, there is Level III /Level IV evidence in the literature supporting the role of LITT in patients with recurrent GBM/high-grade gliomas, metastasis and radiation necrosis. There is a paucity of data regarding other indications of LITT. However, trials are underway and are likely to provide significant level of evidence supporting the efficacy of LITT in a variety of the above-mentioned indications in coming years.
