**6. Long-term sequelae**

The high cure rate achieved in pediatric CNS tumors is greatly attributable to refined neurosurgical procedures, the advancement in RT as well as chemotherapy and the multidis‐ ciplinary team decisions for treatment. However, with prolonged survival and on reaching adulthood, the incidence of late effects becomes more apparent. A majority of long-term survivors have at least one chronic medical sequelae [61]. These complications include endocrinopathy, osteoporosis, cerebrovascular disease, neurological and neurosensory dysfunction, secondary neoplasms, as well as psychological consequence and neurocogni‐ tive impacts.
