**The Role of Exercise in Chemotherapy-Induced Peripheral Neuropathy**

Karen Y. Wonders and Brittany Stout

Additional information is available at the end of the chapter

http://dx.doi.org/10.5772/62839

#### **Abstract**

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434 Neurooncology - Newer Developments

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Chemotherapy-induced peripheral neuropathy (CIPN) is the most common neurologi‐ cal side effect of chemotherapy and is characterized by damage to the nervous system that is a direct result of the medications associated with chemotherapy. Often, this damage to the central nervous system pain pathways results in neuropathic pain described as burning, paroxysmal, stabbing, or elective shock-like and accompanied by pins-andneedles sensations and itching. The presence and severity of neuropathic pain is often shown to be associated with impairments in walking, general activities, sleep, work, mood, enjoyment of life, and relationships with others. Treatment of neuropathic pain due to CIPN often requires a multidisciplinary approach due to the broad variety of symp‐ toms and their negative impact on quality of life. To provide treatment strategies that are effective for patients, they should include a combination of pharmacological agents and exercise rehabilitation. Exercise rehabilitation programs should be designed in order to help patients familiarize themselves to changes in physical functioning. The goals of the program should target three main areas: maximize functional capacities, prolong or maintain independent function, and improve quality of life.

**Keywords:** Cancer, Exercise, Neuropathy, Chemotherapy, Rehabilitation
