**1. Introduction**

The year 2016 continues to be both an enlightening and an exciting year for advances in the investigation and management of high-grade gliomas. The hallmark of glioblastomas is their molecular and genetic heterogeneity, the ability to infiltrate diffusely and undergo rapid neoangiogenesis, while actively challenging our current combinatorial therapeutic approach. At the time of writing, over 230 clinical trials were open in the USA, with ongoing recruitment or due to start. This overview of current trends will involve the details of the molecular markers now in use for both the diagnosis and prognostication of high-grade gliomas, updates on neuroimaging guidelines for both de novo and secondary high-grade gliomas, and the discussion of potential adjuvant therapies to the current standard of care.

© 2016 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
