**5.4. What to expect?**

Although DIPG still remains a lethal cancer with an abysmal prognosis, scientists and physicians have for the first time the appropriate tools and knowledge to change the out‐ come of this disease in children affected with DIPG. The new generation of DIPG clinical trials will focus on new studies of the molecular landscape diversity of children affected with this cancer and will aim to assess the tumor, identify tumor targets, select appropriate agents, and determine the adequate dosing for a treatment selection.

Finally, it is also crucial that the collaborative efforts in this disease continue, given the small number of patients and the difficulty to obtain tumor tissue. The historical tragedy of DIPG should not discourage researchers and physicians from continuing forward. The recent data show improved knowledge that we never previously had about this devastating childhood cancer—and this improvement is a substantial step in opening novel avenues for promising approaches.
