**8. Conclusion**

With advancement in the technology and increased data on ECM components, it was realized that many diseases have a close relation with the composition of ECM in the affected tissue.

ECM composition, in some conditions, gives us a view about the prognosis and progression of disease whereas in others it can give information about the cause and pathophysiology of the disease. With better understanding of ECM one can develop new treatment and follow-up models. Also better knowledge of ECM is essential for tissue engineering. Although there is a lot of data on ECM subject there are still needs for well-planned clinical trials, which can change our perspective on this subject.
