**Author details**

Veronica Iacovacci\* , Gioia Lucarini, Leonardo Ricotti and Arianna Menciassi

\*Address all correspondence to: v.iacovacci@sssup.it

The BioRobotics Institute, Scuola Superiore Sant'Anna, Pisa, Italy

### **References**


potential applications in biomedical engineering and microrobotics. Biomedical Microdevices. 2015;17(6):1–7. doi:10.1007/s10544-015-0024-0

[14] Canham L. Handbook of porous silicon. Springer; 2014.

**References**

10.1038/nrd3799

52 Lab-on-a-Chip Fabrication and Application

s11517-010-0611-4

73.061919

CRC Press; 2015.

S0006-3495(03)75069-3

[1] Neuži P, Giselbrecht S, Länge K, Huang TJ, Manz A. Revisiting lab-on-a-chip technol‐ ogy for drug discovery. Nature Reviews Drug Discovery. 2012;11(8):620–32. doi:

[2] Abgrall P, Gue AM. Lab-on-chip technologies: making a microfluidic network and coupling it into a complete microsystem—a review. Journal of Micromechanics and

[3] Bhagat AA, Bow H, Hou HW, Tan SJ, Han J, Lim CT. Microfluidics for cell separation. Medical & Biological Engineering & Computing. 2010;48(10):999–1014. doi:10.1007/

[4] Abbott J, Nagy Z, Beyeler F, Nelson B. Robotics in the small. IEEE Robotics and

[5] van Reenen A, de Jong AM, den Toonder JM, Prins MW. Integrated lab-on-chip biosensing systems based on magnetic particle actuation—a comprehensive review.

[6] Furlani EP, Ng KC. Analytical model of magnetic nanoparticle transport and capture in the microvasculature. Physical Review E. 2006;73(6):061919. doi:10.1103/PhysRevE.

[7] Jiles D. Introduction to magnetism and magnetic materials. Taylor and Francis Group

[8] Martel S. Magnetic nanoparticles in medical nanorobotics. Journal of Nanoparticle

[9] Furlani EP. Permanent magnet and electromechanical devices: materials, analysis, and

[10] Zborowski M, Ostera GR, Moore LR, Milliron S, Chalmers JJ, Schechter AN. Red blood cell magnetophoresis. Biophysical Journal. 2003;84(4):2638–45. doi:10.1016/

[11] Plouffe BD, Murthy SK, Lewis LH. Fundamentals and application of magnetic particles in cell isolation and enrichment: a review. Reports on Progress in Physics. 2014;78(1):

[12] Lewin M, Carlesso N, Tung CH, Tang XW, Cory D, Scadden DT, Weissleder R. Tat peptide-derivatized magnetic nanoparticles allow in vivo tracking and recovery of

[13] Iacovacci V, Lucarini G, Innocenti C, Comisso N, Dario P, Ricotti L, Menciassi A. Polydimethylsiloxane films doped with NdFeB powder: magnetic characterization and

progenitor cells. Nature Biotechnology. 2000;18(4):410–4. doi:10.1038/74464

Automation Magazine. 2007 J;14:92–103. doi:10.1109/MRA.2007.380641

Lab on a Chip. 2014;14(12):1966–86. doi:10.1039/C3LC51454D

Research. 2015;17(2):1–5. doi:10.1007/s11051-014-2734-2

applications. Academic Press; 2001.

016601. doi:10.1088/0034-4885/78/1/016601

Microengineering. 2007;17(5):R15. doi:10.1088/0960-1317/17/5/R01.


[38] Gao Y, Beerens J, van Reenen A, Hulsen MA, de Jong AM, Prins MW, den Toonder JM. Strong vortical flows generated by the collective motion of magnetic particle chains rotating in a fluid cell. Lab on a Chip. 2015;15(1):351–60. doi:10.1039/C4LC01198H

[27] Pankhurst QA, Connolly J, Jones SK, Dobson JJ. Applications of magnetic nanoparticles in biomedicine. Journal of Physics D: Applied Physics. 2003;36(13):R167. doi:

[28] Zeng J, Deng Y, Vedantam P, Tzeng TR, Xuan X. Magnetic separation of particles and cells in ferrofluid flow through a straight microchannel using two offset magnets. Journal of Magnetism and Magnetic Materials. 2013;346:118–23. doi:10.1016/j.jmmm.

[29] Jeong S, Choi H, Choi J, Yu C, Park JO, Park S. Novel electromagnetic actuation (EMA) method for 3-dimensional locomotion of intravascular microrobot. Sensors and

[30] Kummer MP, Abbott JJ, Kratochvil BE, Borer R, Sengul A, Nelson BJ. OctoMag: An electromagnetic system for 5-DOF wireless micromanipulation. IEEE Transactions on

[31] Ullrich F, Bergeles C, Pokki J, Ergeneman O, Erni S, Chatzipirpiridis G, Pané S, Framme C, Nelson BJ. Mobility experiments with microrobots for minimally invasive intraoc‐ ular Surgery Microrobot experiments for intraocular surgery. Investigative Ophthal‐

[32] Martel S, Mohammadi M, Felfoul O, Lu Z, Pouponneau P. Flagellated magnetotactic bacteria as controlled MRI-trackable propulsion and steering systems for medical nanorobots operating in the human microvasculature. The International Journal of

[33] Khalil IS, Magdanz V, Sanchez S, Schmidt OG, Misra S. Three-dimensional closed-loop control of self-propelled microjets. Applied Physics Letters. 2013;103(17):172404. doi:

[34] Lacharme F, Vandevyver C, Gijs MA. Full on-chip nanoliter immunoassay by geomet‐ rical magnetic trapping of nanoparticle chains. Analytical Chemistry. 2008;80(8):2905–

[35] Liu P, Li X, Greenspoon SA, Scherer JR, Mathies RA. Integrated DNA purification, PCR, sample cleanup, and capillary electrophoresis microchip for forensic human identifi‐

[36] Moser Y, Lehnert T, Gijs MA. On-chip immuno-agglutination assay with analyte capture by dynamic manipulation of superparamagnetic beads. Lab on a Chip.

[37] Dittmer WU, De Kievit P, Prins MW, Vissers JL, Mersch ME, Martens MF. Sensitive and rapid immunoassay for parathyroid hormone using magnetic particle labels and magnetic actuation. Journal of Immunological Methods. 2008;338(1):40–6. doi:10.1016/

Actuators A: Physical. 2010;157(1):118–25. doi:10.1016/j.sna.2009.11.011

mology & Visual Science. 2013;54(4):2853–63. doi:10.1167/iovs.13-11825

Robotics Research. 2009;28(4):571–82. doi:10.1177/0278364908100924

cation. Lab on a Chip. 2011;11(6):1041–8. doi:10.1039/C0LC00533A

Robotics. 2010;26(6):1006–17. doi:10.1109/TRO.2010.2073030

10.1088/0022-3727/36/13/201

2013.07.021

54 Lab-on-a-Chip Fabrication and Application

10.1063/1.4826141

j.jim.2008.07.001

10. doi:10.1021/ac7020739

2009;9(22):3261–7. doi:10.1039/B907724C


Robotics and Automation (ICRA), (pp. 2668–2673). IEEE. doi:10.1109/ICRA. 2011.5980100

