**8. Emulation of the interaction between genes and microRNA species known to be instrumental in the development of the osteoblastic/ odontoblastic phenotype by Mir@nt@n**

The bioinformatics program Mir@nt@n, developed by Le Bechek et al. [64], was used to arrive at high stringency interactions between microRNA species known to be instrumental in the development and stability of osteoblastic and odontoblastic cells from stem cells. The dental = osteoblastic/dentinoblastic genes (being significantly regulated by Vitamin K2 in the present study) described in the present array were fed into the program along with other genes and microRNA-species known to be instrumental in the development and stability (both positively and negatively) of the osteoblastic and/or odontoblastic phenotype:

*Lmcd1, Dmxl2, Abcb4, Slc12a6, Mta1, Pou3f3, Dio2, Camk4, Ppp2r2b, Stard4, Tyk2, Pdcd5, Psenen, Rhob, Rs1, Trpm5, Amelx, DKK1, SP1, SP3, SP7, Runx2, Runx1, NR1/2, ADRB3, Foxc2, PGC1α, PPARA, PPARG, Dio2, UCP1, Adipoq, LEP, BETA3AR/ADRB3R/B3AR, hsa-mir-155, and c/EBPB*.

*Hsa-mir-196a, hsa-mir-16, hsa-mir-455, hsa-mir-339, hsa-mir-125b, hsa-mir-328, hsa-mir-16, hsamir-149, hsa-mir-125b, hsa-mir-760, hsa-mir-133, hsa-mir-29, hsa-mir-27, hsa-mir-23, hsa-mir-320, hsa-mir-26b, hsa-mir-21, hsa-mir-302, hsa-mir-132, and hsa-mir-223*.
