**2. Conclusion**

Until now, a lot of potential epigenetic mechanisms in MS have not been discovered, and also the hypotheses linking nutritional factors and obesity or nutritional compounds have not been proved by prospective epidemiological studies. The relationship among diet, obesity and genetic risk of MS has been studied only occasionally. The included studies were usually focused on a role of vitamin D. Further studies based on both genetic-epigenetic factors and environmental triggers could bring new information about how to determine the MS risk factors more precisely and much earlier in life. Although at present, there is no particular preventive strategy in MS, new findings could help us to work out dietary interventions and other alternative non-conventional therapies.
