**Acknowledgements**

carried out (e.g., taksol or nurophene of a prolongation effect). Platform technologies for a controllable drugs release are very important for the targeted delivery of high toxic antineo‐

Traditional cancer drugs are evenly distributed by the whole organism, thus reaching both the diseased and healthy organs. This problem can be solved with the help of directed DDS (drug delivery system) when the drug is delivered along with a biodegradable polymer used as transport. In this case, the drug is released not immediately, but gradually, in the process of

There exist the target drugs delivering by nanoparticles of a genetic material, DNA or RNA. For the magnetic target influence, the drug or therapeutic radionuclide is attached to magnetic compound, which is entered into the organism, and then concentrated in the area of the target influence by means of a magnetic field (here the implanted constant magnet or the EMF could

The magnetic DDS in its current state is mostly applicable to well-studied tumors, whereas the medical treatment of metastatic and/or small tumors at their early stage of development still remains an unsolved problem. The therapy of emerging tumors implies the development of a new generation of nanoparticles of teradiagnostics type, capable of recognizing small clusters of cancerous cells and delivering the elements (drugs or hyperthermia materials) required for their destruction. Teradiagnostics will ensure a permanent control of the course of treatment

Lately, a number of directions in the molecular visualization sphere have got a wide devel‐ opment via the 3D printing. MRI is one of the most powerful noninvasive methods of visual‐ izations intensively used in clinical medicine [61]. Contrast agents based on the magnetic nanoparticles are one of the most perspective medical applications and are considered as the following MRI-agents generation. Magnetic SPIO are also actively researched as contrast agents for the MRI. New biological applications of these contrast agents are the following: checking of a bloodstream, cancer and tissue engineering scaffolds agents, the MRI contrasts, checking the cells motion, and biomolecular study. In contrast to paramagnetic ions, the SPIO nanoparticles have a higher molecular relaxation. Therefore, in case of their use under low concentration for the bloodstream checkup, they can have some advantages. The MRI yields to positron spectroscopy in its resolution but it gains in its cost. An inexpensive MRI procedure with the SPIO nanoparticles use, distinguishes tumor metastasis of approximately 1 mm size.

In this chapter, we reviewed the modern tendency to fabricate the 3D printing of functionally graded structures from the polymer-covered nanocomposites: inkjet 3D printing of optical nanostructures; 3D-printing of polymer nanocomposites with specific viscosity, osteoconduc‐

with a concurrent checkup of the drug delivery results and influences.

plastic drugs.

252 New Trends in 3D Printing

be used).

the polymer degradation.

**7.4. Magnetic resonance imaging**

**8. Conclusions**

Prof. I. Shishkovsky is grateful for the financial support provided by the Russian Science Foundation (grant no. 15-19-00208).
