**DNA G-Quadruplex as a Reporter System for Sensor Development**

Qiuting Loh and Theam Soon Lim

Additional information is available at the end of the chapter

http://dx.doi.org/10.5772/61580

#### **Abstract**

The versatile DNA G-quadruplex structure has emerged as an interesting alternative re‐ porter system applied in different biosensor platforms. In comparison to the conventional reporter systems like enzymatic or fluorescent, DNA G-quadruplex has some distinct ad‐ vantages, as it is thermostable, easy to produce, low cost and most importantly able to be amplified. Such remarkable advantages have led many researchers to exploit DNA Gquadruplex as the reporter system in colorimetric, fluorescence and luminescence sen‐ sors. There has also been integration of DNA G-quadruplex with electrochemical methods and quantum dot for sensing applications. Therefore, this chapter highlights some recent examples of different biosensor platforms that use DNA G-quadruplex as a reporter system with different detection methods.

**Keywords:** G-quadruplex, Biosensor, Protein Detection, DNA Detection, Metal Detection
