**6. Business issue**

To biopharma companies, protein engineering/evolution platforms must provide solutions to improve the throughput, safety, biodistribution, activity and frequency of dosing of designed protein, evading intellectual property issues and reducing manufacturing costs, especially in the late process of development and production stages. Intellectual property rights are definite issues, the intellectual property situations of antibodies are obscure as previously described. An alternative scaffold equips the same abilities as antibody does is a valuable prospect and desired to avoid the complex intellectual property landscape of antibody. A protein scaffold can access to a cardinal target and circumvent intellectual property issues that does not mean that it is necessarily a platform worth investing in. The successfully designed protein must equip an improved performance and provide solutions to the concerned points described above.
