**7. References**

144 Biomedical Science, Engineering and Technology


Fig. 9. The proposed mechanism of anti-glycation action of poly(amido)amine dndrimers

the presence of poly(amido)amine dndrimers, generation 4.0 (PAMAM G4.0).

Under conditions of excessive glucose the model protein (bovine serum albumin, BSA) undergoes extensive glycation (A), which becomes retarded and reduced to a large extent in

Diabetes is not merely a disease of impaired insulin sensitivity or insulin release, but may be a global metabolic dysfunction, including, among others, the collapse of the mitochondrial energy system. The role of the mitochondria in the metabolism associated with the pathophysiology of diabetes seems unique, mainly because a generation of ROS (which seem a natural part of mitochondrial physiology) constitutes a major treat in the development of diabetic sequelae. ROS play the central role in mediating various metabolic

of its anti-glycation activities (Watala et al., 2009).

(PAMAM).

**6. Conclusion** 


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