**7. Conclusion**

The knowledge about the scaffold is not enough to establish rules to predict its biochemical functions. There are still some technical limitations and the development of the scaffold is confined. Peptides with a CSαβ motif bear many excellent properties and can serve as an alternative protein scaffold for biomedical application. Natural products containing peptides with a CSαβ motif have been therapeutically used for hundreds of years. Some of the purified peptides are tested and have low toxicities to mammalian species. Prudential is needed when recruiting new proteins/peptides as treatments for diseases. The intellectual property situation of peptides with a CSαβ motif is not as complex as antibody, especially in biomedical application (Yang & Lyu, 2008). For its original expression in plant, the engineered proteins with medicinal effect can be expressed in transgenic crops and diseases can be controlled through foods. To predict the biochemical functions of peptides with a CSαβ motif is difficult, some prediction tools have been developed to predict functions of protein from the primary structure, but how proteins interact with their counterparts has to be considered. Folding and post-translational modification of proteins has to be thought over. We believe that peptides with a CSαβ motif will be an alternative scaffold and can be widely applied in biomedical utilities.
