**1. Introduction**

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complexity of multi-channel EEG indicates change of human brain functional state after a single dose of a nootropic drug. Electroencephalogr Clin Neurophysiol *86*, A Mars manned mission is practically impossible without resolving some problems on the ground with test subjects involved related to crew life-support psychological stability, fitness to work during a long-duration, self-sustained space mission. One of the problems to be resolved in spaceflight is the crew's health and fitness work. These factors are possible to investigate in a ground experiment to make more effective preparation for interplanetary missions including a Mars mission. Another problem lies in failure-free functioning of onboard systems and first of all the Integrated Regenerative Life-Support System (IRLSS) in the Mars-500 project. The crew plays a key role in maintaining system operability and reliability the entire mission.

In order to make long-duration, self-sustained interplanetary missions a reality it is necessary to provide crew support and its activities under conditions essentially different from those of earth orbital flights.

Specifics of interplanetary flights include:

	- expansion of functions of IRLSS functions related to crew personal;
	- prompt parameters of the crew's environment under spaceflight conditions;
	- the necessity of carrying out the crew's medical control and strain relief on-board the spacecraft.
	- lack of renewal expendables units;
	- the systems incorporated in the IRLSS architecture shell ensure trouble-free performance over the entire flight with minimal spare parts and expendables required;
	- the necessity of decision-making by crew as identification and localization of possible off-normal situations related to the IRLSS due to limited intervention on the part of the ground mission control center to control the crew's actions.

Investigations into prolonged influence of the conditions of self-sustained interplanetary flight on crewmembers' intellectual faculties in operation of the IRLSS are of prime importance to make a mission a success and cannot be predicted on the basis of theoretical and experimental data, ground experiments conducted shall be aimed first of all at evaluating the operator's effective activities and his psychological condition (attention, vigilance, perception, memory, thinking training) in combination with physiological parameters of the central and vegetative nervous systems.

Actual participation of test subjects in serving operational standard system at first phases of ground simulation of spaceflight to Mars is extremely complicated and economically unprofitable. A more rational approach is the application of standard system virtual simulators interacting with simulation models for both environment and crew as a load component and integrated in a single Hardware/Software Complex for Serving Operational Systems by crew (HSCSOS) intended for system functioning in normal, off-normal and emergency situations resulted in failure of some systems and deviation of environment controllable parameters from specified values. Those situations may include human factor (crew members' decline in fitness to work, activities, etc.).

The purpose of this charter is analysis of all possible approaches to development of similar complexes based on simulation taking into account a long-duration stay of Man in confined space. The analysis results may be used in development of similar hardware/software complexes to analyze complicated human-machine interaction and specialist training for various-purpose Man-Made Ecosystems (MMES).
