**2. Impact of hyperglycaemia on cellular biochemistry/metabolism – overview of the recent achievements in the field**

Glycation and oxidative stress are two important processes known to play a key role in the etiopathology of complications in numerous disease processes. Oxidative stress, either via increasing reactive oxygen species (ROS), or by depleting the antioxidants, may modulate the genesis of glycated proteins *in vitro,* as well as *in vivo*.
