**7. References**

774 Biomedical Science, Engineering and Technology

ccess and study residual clinical samples made available during routine joint surgery.

Genetic variations in IL28B on the natural history of hepatitis B and C and their treatment

Defining the function of CD161+ CD8+ T cell subsets in HIV infection and their response

The metabolic impact of Darunavir/ritonavir maintenance monotherapy after successful

The IDB's skill and expertise is also being currently utilized to provide research support for clinical studies performed locally, these are often intervention studies and hence require independent ethical permissions from LRECs other than that of the IDB. The largest of these is currently the KCL Human Immune Response Dynamics (HIRD) study. This ground-breaking longitudinal study is investigating the response in humans to vaccination with the H1N1 ('swine flu') influenza vaccine using a protocol was approved by the Brent LREC (09/H0717/88). Briefly, the study involves the IDB collecting and archiving of peripheral venous blood samples from overnight fasted volunteers at the CRFs. Two pre-vaccination samples are harvested and, after vaccination (with PandremixTM H1N1 vaccine: GlaxoSmithKline Biologicals Ltd), a further four samples are collected until six weeks post vaccination. To date over 170 volunteers have completed the course of bleeds and vaccination.

This Chapter has summarized the development of some key ethical concepts which specifically impinge upon the newly emerging discipline of human tissue biobanking in terms of classical notions as well as historical turning points which have resulted in current UK legislation. In particular, this paper highlights the fundamental dilemma between the rights of the individual and their duty to the society and describes in practical terms how the KCL Infectious Diseases Biobank is regulated and managed. Whilst, the essential ethical

Investigating the effect of Maraviroc on Microbial Translocation in HIV infected

T-Regulatory cells in HIV infection Ps20 studies in HIV infections

Naive B cell responses in older people

Non-infectious co-morbidities in HIV infection

individuals who are receiving antiretroviral therapy

**4.8 The IDB as a contract service** 

response.

to therapy

**5. Conclusions** 

The roles of vpu and tetherinin HIV/AIDS pathogenesis

The control of inflammation in immunity and autoimmunity

Gene expression signatures of HIV-1 infection *in vivo* and *in vitro*

Renal function and bone homeostasis in patients starting HAART

viral suppression with standard Atripla in HIV-1-infected patients

Table 2. Some of the types of studies currently accessing the IDB.


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