**8. Conclusion**

With the technology of NGS, prenatal care has reached a new era. It has changed prenatal algorithms and has led to a reduction of invasive procedures which was one of the main goals of this technology [65,71]. At present, the main domain of NIPT is the detection of the three most common aneuploidies trisomy 21, 13, and 18, in singletons. However, further aneuploi‐ dies like sex chromosomal aneuploidies and some microdeletions are offered today in a clinical setting and research is aiming on sequencing the whole genome by a non-invasive approach with the ultimate dream of thereby opening an early "window of opportunity" for fetal therapy.
