**Analysis of Haplotype Sequences**

Sally S. Lloyd, Edward J. Steele and Roger L. Dawkins

Additional information is available at the end of the chapter

http://dx.doi.org/10.5772/61794

#### **Abstract**

In this era of whole-genome, next-generation sequencing, it is important to have a clear understanding of the concept of "haplotype". We show here that most of the important regions of the genome can be described in terms of polymorphic frozen blocks (PFB). At each PFB, there are numerous, even hundreds, of alternative ancestral haplotypes. Haplotypes, not genes, can be regarded as the principal unit of inheri‐ tance. We illustrate how sequence data can be analysed to reveal and define these ancestral haplotypes.

**Keywords:** Ancestral haplotypes, Polymorphic frozen blocks, Genomic evolution
