**Computational Analysis and Integration of MeDIP-seq Methylome Data**

Gareth A. Wilson and Stephan Beck

Additional information is available at the end of the chapter

http://dx.doi.org/10.5772/61207

#### **Abstract**

The combinatorial number of possible methylomes in biological time and space is astro‐ nomical. Consequently, the computational analysis of methylomes needs to cater for a va‐ riety of data, throughput and resolution. Here, we review recent advances in 2nd generation sequencing (2GS) with a focus on the different methods used for the analysis of MeDIP-seq data. The challenges and opportunities presented by the integration of methylation data with other genomic data types are discussed as is the potential impact of emerging 3rd generation sequencing (3GS) based technologies on methylation analysis.

**Keywords:** DNA methylation, methylome, immuno precipitation, analysis pipeline
