**6. Conclusions**

The selection pressure exerted by insecticides for more than six decades on the populations of *Ae. aegypti* in Mexico has generated widespread resistance to a variability of insecticides and in the last 15 years to pyrethroids. It is essential that we consider actions to avoid strong resistance between pyrethroids and alternative adulticides. Going forward, strategies must include resistance monitoring, the development of advanced tools for detecting multiple insecticide resistance, and practical tools for efficient vector control.
