Emmanuel Chanda

[87] Brown TM, Hooper GHS. Metabolic detoxication as a mechanism of methoprene re‐

[88] Brown TM, Brown AWA. Accumulation and distribution of methoprene in resistance

[89] Dame DA, Wichterman GJ, Hornby JA. Mosquito (*Aedes taeniorhynchus*) resistance to methoprene in an isolated habitat. J. Am. Mosq. Control Assoc. 1998; 14:200–203. [90] Cornel AJ, Stanich MA, Farley D, Mulligan FS III, Byde G. Methoprene tolerance in *Aedes nigromaculis* in Fresno County, California. J. Am. Mosq. Control Assoc. 2000;

[91] Cornel AJ, M. Stanich A, McAbee RD, Mulligan FS III. High level methoprene resist‐ ance in the mosquito *Ochlerotatus nigromaculis* (Ludlow) in central California. Pest

[92] Schaefer CH, Mulligan FS III. 1991. Potential for resistance to pyriproxyfen: a promis‐ ing new mosquito larvicide. J. Am. Mosq. Control Assoc. 1991; 7:409–411.

[93] Walker AL, Wood RJ. Laboratory selected resistance to diflubenzuron in larvae of

[94] Ferrari JA, Georghiou GP. Effects of insecticidal selection and treatment on reproduc‐ tive potential of resistant, susceptible, and heterozygous strains of the southern

[95] Rivero A, Vézilier J, Weill M, Read AF, Gandon S. Insecticide control of vector-borne diseases: when is insecticide resistance a problem? PLoS Pathog. 2010; 6(8): e1001000.

[96] Alout H, Ndam NT, Sandeu MM, Djégbe I, Chandre F, Dabiré RK, Djogbénou LS, Corbel V, Cohuet A. Insecticide resistance alleles affect vector competence of *Anophe‐ les gambiae s.s.* for *Plasmodium falciparum* field isolates. PLoS One. 2013; 8(5): e63849.

[97] Liu R, Gourley SA. Resistance to larvicides in mosquito populations and how it

could benefit malaria control. European J. Appl. Math. 2013; 24:415–436.

sistance in *Culex pipiens pipiens*. Pestic. Biochem. Physiol. 1979; 12:79–86.

*Culex pipiens pipiens* larvae. Ent. Exp. Appl. 1980; 27:11–22.

16:223–238.

154 Insecticides Resistance

Manag. Sci. 2002; 58:791–798.

*Aedes aegypti*. Pesti. Sci, 1986; 17:495–502.

doi:10.1371/journal.ppat.1001000.

house mosquito. J. Econ. Entomol. 1981; 74: 323–327.

Additional information is available at the end of the chapter

http://dx.doi.org/10.5772/61301

#### **Abstract**

In the past decade, there has been rapid scale-up of insecticide-based malaria vector con‐ trol in the context of integrated vector management (IVM). But, the continued efficacy of vector control interventions is threatened by the selection of insecticide resistance. Evi‐ dence of insecticide resistance operationally undermining malaria vector control pro‐ grammes is invariably mounting and is resulting in policy changes. Monitoring and management of resistant disease vectors is essential to limit the selection and spread of insecticide resistance and to maintain the effectiveness of vector control. Thus, countries are encouraged to implement pre-emptive insecticide resistance management (IRM) strat‐ egies against malaria vectors according to the Global Plan for IRM. However, substantial challenges for implementation exist at country level. The IVM strategy provides a poten‐ tial platform that could be exploited for enhanced national strategic IRM planning and operationalisation. Nevertheless, significant coordinated response among stakeholders and political commitment is needed for timely and effective policy implementation with‐ in the context of a national health system.

**Keywords:** Malaria vector control, integrated vector, management strategic planning, in‐ secticide resistance management
