**7. Conclusion**

Spirotetramat acts as a biosynthesis inhibitor of lipids and presents good activity against the most important aphids including whitefly. The activity of spirotetramat predominates in the immature stages of development in aphids, causing on occasion an incomplete ecdysis and causing a reduction in productiveness and fertility. The results suggest that spirotetramat can be used in a secure program of integrated pest management involving biological control, however, in this respect there is contradictory information; each case should be evaluated independently depending on the organism used for biological control.

Once spirotetramat is found inside the plant, it is transformed to its enol form and to the metabolite cetohydroxy, both are two main degradation compounds. The possibility of leaching of spirotetramat into subterranean waters is low according to the results; the proba‐ bility of accumulating in the soil is also very low. On the other hand, based on the results in aquatic environment, under certain conditions there can exists the possibility of accumulation in this system; for this reason adequate care should be taken in applications near aquatic systems. Furthermore, no reports were located that indicated the possibility of spirotetramat accumulation in the air. Lastly, up to this moment there have been proteomic studies suggest‐ ing certain forms of resistance to spirotetramat in cotton aphids.
