**5. Conclusion**

There are a variety of hormonal actions and interactions involved in the regulation of important PTC functions such as receptor-mediated endocytosis and the reabsorption of sodium and phosphate. The impaired counterbalance of these hormones is likely to be associated with the development and/or progression of CKD. Elucidation of the mechanisms of such hormonal actions and interactions would therefore be of great benefit in the future development of novel therapeutic strategies for CKD.
