**4. Conclusion**

It is possible that normal human genomic DNA to be used as materials for homologous genetic recombination to repair defective genes *in vivo*. Normal human genomic DNA or normal genomic DNA fragments can be transferred into somatic cells/stem cells from a patient by microinjection, transfection, and electroporation. The corrected cells can be transplanted back to the same patient. Cells seem to be able to tolerate foreign DNA without immunological rejections; thus, the method described above may be an effective, relatively simple gene therapy method, and it may have no or less immunological reactions and rejections. Certainly, this possible approach of gene therapy should be performed only after strict and well-designed cellular and animal experiments and human clinical trials.
