**6. Conclusions**

Ultrasound mediated gene delivery with acoustically active carriers (e.g. microbubbles) is a promising field that affords the potential for high levels of expression in the target tissue without the adverse bioeffects of viral-based carriers. The field is early in its development however as no clinical studies have yet been performed as of the time of preparation of this manuscript. Clinical development of this promising field will require identification of biological targets in areas of medical need and multi-disciplinary collaborations between material scientists, biologists and biopharma.
