**5. Conclusive Summary**

Thanks to the improvement in the diagnostic and therapeutic pathways, the number of cancer survivors is progressively increasing, as well as the number of metastatic patients. Taking into consideration all primary solid tumors, the liver represents the most frequent site involved by distant metastasization, also due to its anatomical position and its important blood reception from the majority of digestive organs.

Despite the abundant literature and guidelines about colorectal liver metastases, there is still great debate about the treatment strategy in the case of non-colorectal ones. Anyway, many experiences have been published in the last decades about surgical treatment of the most frequent non-colorectal liver metastases. In particular, we reviewed surgical strategies in the case of hepatic secondaries from neuroendocrine tumors, gastric cancer, and breast cancer. And in every case, the literature suggests a role for hepatic surgery for patients with resectable hepatic disease.

However, the number of considered patients is often very limited as well as the statistical strength of the current literature. Therefore, further randomized controlled trials are required in order to better define the benefit of hepatic surgery in these kinds of patients.
