**8. Clinical measurements of disease severity and how they predict prognosis**

Whilst recognising the importance of tailoring care of patients with CF to the individual genotypes and associated co-morbidities is essential, many of these factors are established and in many ways less dynamically modifiable than others in clinical practice.

The prognostic value of more dynamic markers of clinical condition offer more practical longterm targets around which to focus treatment and goals in the individual patient. On a day to day basis, these parameters guide practice and stratify patients in terms of expected outcomes.
