**Acknowledgements**

The authors would like to thank all individuals with whom we have worked over the years in this challenging yet exciting field of study. We would also like to acknowledge investigators who have contributed significantly to the fields of cyclic nucleotide signaling, vascular biology, and the cardiovascular sciences but whose works were not cited in this chapter due to formatting limitations. Work in the preparation of this book chapter was supported by the Post 9/11 GI Bill, Award Number R01HL81720 from the National Heart, Lung, and Blood Institute, National Institutes of Health, by grants from the American Heart Association (AHA), an ECU Brody School of Medicine Seed/Bridge Grant, and a Brody Brothers Endowment Fund Award. We thank you all for your generous support. This content is solely the responsibility of the authors and does not necessarily represent the official views of the American Heart Associa‐ tion, the National Heart, Lung, and Blood Institute, the National Institutes of Health, or the Brody Brothers Endowment Fund.
