**2. Skeletal muscle growth and regeneration**

Nowadays, it is obvious that skeletal muscle growth and regeneration is firmly linked to the activity of satellite cells adjacent to extrafusal and intrafusal muscle fibers. Intact skeletal muscle encloses satellite cells in the quiescent state, with a dense nuclear chromatin (hetero‐ chromatin), fine rim of the cytoplasm, and little organelles. Covered by a thin layer of basement membrane, the satellite cell rests closely applied to the sarcolemma of the muscle fiber (Figure 1). The notion that satellite cells donate nuclei to a growing or regenerating fiber, one at a time, is widely known from a half of the century [5]. Although quiescent in normal skeletal muscle, satellite cells (named by Mauro, [6]) become activated and recruited to the cell cycle when there is a requirement to increase myonuclear number [7]. In response to signals accompanying skeletal muscle injury, denervation, exercise, or work overload, the activation reverses the morphology of satellite cells to lower chromatin density (euchromatin), expanded cytoplasm, and additional organelles [8–9]. Several lines of evidence suggest numerous molecules including hormones, growth factors, cytokines, and reactive species as potent incentives in the activation of satellite cells, yet it is still not clear how these muscle progenitors become receptive to the stimuli. Rearrangement of plasma membrane lipids, proteins, and their glycosyl and lipid conjugates might be considered as possible beginning of satellite cell commencement to sense some of the signals. Despite great biological and clinical interest, our knowledge of *in vivo* N-glycosylation sites – a prerequisite for detailed functional understanding – is still very limited [10]. Similarly, the conception of plasma membrane lipidome input to sense and transduce the signals for the activation of satellite cells is limited [11]. Thus, any endeavor intended to decipher the details and mechanisms hidden behind the dynamic changes of plasma membrane organization is an attractive approach with promising perspective for future clinical application in the treatment of skeletal muscle myopathies.
