**Obese Childhood Dyslipidemia Management Beyond Statins — MUFA, PUFA, and Sea-buckthorn Supplements**

Bogdana Virgolici, Laura Anca Popescu, Horia Virgolici, Daniela Elena Casariu, Olivia Timnea and Maria Mohora

Additional information is available at the end of the chapter

http://dx.doi.org/10.5772/61001

#### **Abstract**

[90] Yatsuya H. Race-and sex-specific associations of obesity measures with ischemic stroke incidence in the Atherosclerosis Risk in Communities (ARIC) study / H. Yat‐ suya, A.R. Folsom, K. Yamagishi et al. // Stroke. – 2010. – Vol. 41, N 3. – Р. 417-425. [91] Yazdanyar A. Role of phospholipid transfer protein in high-density lipoprotein– mediated reverse cholesterol transport / A. Yazdanyar, C. Yeang, X.-C. Jiang // Cur‐

[92] Ye J. Mechanisms of insulin resistance in obesity / J. Ye // Frontiers in Medicine. –

[93] Yeap B.B. Androgens and cardiovascular disease / B.B. Yeap // Current Opinion in

[94] Zagayko A.L. Antioxidant complexes and lipoprotein metabolism – experience of grape extracts application under metabolic syndrome and neurogenic stress / A. L. Zagayko, G.B. Kravchenko, M.V. Voloshchenko et al. // Lipoproteins - Role in Health

[95] Zagayko A.L. Antioxidant status changes in golden Syrian hamsters with experimen‐ tal metabolic syndrome / A.L. Zagayko, L.N. Voronina, P.A. Kaliman et al. // Ukraini‐

[96] Zagayko A.L. Grape polyphenols increase the activity of HDL enzymes in old and obese rats / A.L. Zagayko, G.B. Kravchenko, O.A. Krasilnikova et al. // Oxidative Medicine and Cellular Longevity. – 2013, art. 593761, 7 pages (http://www.hinda‐

[97] Zagayko A.L. The sexual differences of changes in some lipid metabolism parameter in syrian hamster with experimental metabolic syndrome under hypercaloric diet / A.L. Zagayko, L.N. Voronina, K.V. Strelchenko // Ukrainian Biopharmaceutical Jour‐

[98] Zerradi M. Androgens, body fat distribution and adipogenesis / M. Zerradi et al. //

[99] Zhang Z. Role of cholesterol ester mass in regulation of secretion of ApoB100 lipo‐ protein particles by hamster hepatocytes and effects of statins on that relationship / Z. Zhang, K. Cianflone, A.D. Sniderman // Arteriosclerosis, Thrombosis, and Vascu‐

Endocrinology, Diabetes and Obesity. – 2010. – Vol. 17, N 3. – Р. 269-276.

rent Atherosclerosis Reports. – 2011. – Vol. 13, N 3. – Р. 242-248.

and Diseases. – Rijeka, Croatia: InTech, 2012. – P. 445-488.

an Biochemistry Journal. – 2008. – Vol. 80, N 3. – P. 103-109.

Current Obesity Reports. – 2014. – Vol. 3, N 4. – Р. 396-403.

2013. – Vol. 1, N 7. – P. 14-24.

58 Lipoproteins - From Bench to Bedside

wi.com/journals/omcl/2013/593761/).

nal. – 2008. – Vol. 1, N 1. – P. 31-33.

lar Biology. – 1999. – Vol. 19. – P. 743-752.

The dyslipidemia pattern usually associated with childhood obesity consists of a combination of elevated triglyceridemia, decreased plasma high density lipoprotein cholesterol concentration and LDL-c concentration at the upper limit of the normal range. This type of dyslipidemia is associated with dense and small LDL, which are proatherogenic. High circulating levels of oxidized LDL were described in extreme pediatric obesity, in children with high fructose intake and are associated with insulin resistance. The worst effect on blood lipids have trans and saturated fatty acids. But the amount of total energy intake plays more important role in lipid profiles. In childhood obesity it seems that insulin resistance precedes the development of the metabolic syndrome feature and insulin resistance is correlated with dyslipidemia. Insulin resistance increases free fatty acid flux to the liver by decreased inhibition of lipolysis and also by increased de novo lipogenesis. Fish oil is rich in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and has hypotriglyceridemic effect in comparison to monounsaturated fatty acids. Passive in utero exposure to a hyperli‐ pidemic environment may have programmed these children for accelerated athero‐ sclerosis. The infant formula should be enriched with long chain fatty acids because this supplementation is associated with lower blood pressure during later childhood. In obese children, supplements with Omega-3 polyunsaturated fatty acids improve lipid profile, blood pressure values and inflammatory markers. Omega-3 fatty acids prevent metabolic syndrome, by reducing hepatic steatosis, visceral fat, by reducing serum triglycerides and improving insulin sensitivity. Potentially all compounds of

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the Sea buckthorn berry, including flavonols, carotenoids, fatty acids, tocopherols and phytosterols can affect the metabolic profile. Special features of the berry oils are high proportions of palmitoleic acid as well as vitamin E, carotenoids, and sterols. The palmitoleic acid stimulates muscle insulin action, suppresses hepatosteatosis and prevent the deleterious effects of saturated fatty acids and high glucose on human pancreatic beta-cell turnover and function. Phenolic compounds and flavonoids from sea buckthorn ameliorate bodyweight, blood glucose, and serum lipid profile. By reducing triglyceridemia and by improving the blood pressure levels, sea buckthorn pulp oil may prevent metabolic syndrome in obese children. The treatment is recommended in hypertriglyceridemic waist phenotype obese children. Omega-3 supplements and sea buckthorn pulp oil supplements reversed the carotid intima media thickness values in obese children and they have beneficial effects in childhood obesity

**Keywords:** MIFA, PUFA, childhood obesity
