Preface

Chapter 7 **Biological Concepts on Bisphosphonate Treated Patients in**

Chapter 8 **Platelet-rich Plasma (PRP) in Orthopedics and Traumatology**

Marieta Georgieva, Kaloyan Georgiev and Peter Dobromirov

Moosa Patel, Vinitha Philip, Atul Lakha, Sugeshnee Pather, Muhammed Faadil Waja, Lucille Singh and Mohamed Arbee

Bogdanka Andric, Aleksandar Andric and Mileta Golubovic

Chapter 12 **Pharmacological Properties of Monoclonal Antibodies Directed**

Kaloyan Georgiev and Marieta Georgieva

Chapter 13 **Human Vector-Borne Transmissible Parasitic Diseases in**

**Oral Surgical Procedures 127**

Pencho Kossev and Tsvetan Sokolov

Metodi Abadzhiev

**VI** Contents

**— Review 173**

Chapter 9 **Probiotics and Immunity 197**

Chapter 11 **Multicentric Castleman's Disease 247**

**Against Interleukins 261**

**Montenegro 287**

Chapter 10 **Bruton's Disease 217** Yıldız Camcıoğlu

**Section 3 Research Data 245**

**the Context of Increasing Patient Life Quality and the Need for**

*Medicus curat, natura sanat!*

(meaning, Doctor cures, nature saves!)

This book is a second attempt of a group of distinguished international authors to reveal out a number of disputable topics in regard to immunopathology, immunoregulation, immuno‐ suppression, immunostimulation, immunotherapy, immune status, and clinical immunolo‐ gy as a whole.

Generally speaking, immunopathology (IP) is a branch of medicine that deals with immune responses associated with disease. It has various manifestations, both clinically expressed and latent processes, which, however, are also a high risk to the potential patient. IP in‐ cludes the study of the pathology of an organism, organ system, or disease with respect to the immune system, immunity, and immune responses.

The main aim of the authors of the book is to take a deep look into serious immune disor‐ ders. The chapters reflect updated information of the current development and perspective of modern immunology in regard to immune diseases, and they tend to expand the present knowledge on the specific topics included in the content.

Defects or malfunctions in the immune response can provoke illness or disease. Such disor‐ ders are generally caused by an overactive immune response, manifested as hypersensitivity reactions, an inappropriate reaction to self, manifested as autoimmunity, or ineffective im‐ mune responses, known as immunodeficiency.

This book is a step forward to the positive discussion of proper diagnosis and appropriate therapeutic decisions, because *Bene diagnoscitur, bene curato*r (meaning, a disease known is half cured).

It is directed to all biomedical researchers and clinicians, from students to professionals, aca‐ demic scientists, university professors, and specialists.

We, the authors, editors, and technical supervisors of the InTech Open Access Publisher, are fully aware that our product, the new book *Immunopathology and Immunomodulatio*n could be a useful tool in the hands of everybody who is keen and ambitious to know more about immunology.

**Prof. Dr. Krassimir Metodiev, MD, PhD, DSc(Med),**

Head, Dept. of Preclinical and Clinical Sciences, Medical University of Varna, Bulgaria, President of IMAB (www.imab-bg.org), Vice-President of FESCI, Referent and Fellow of UICC

**Section 1**
