**Author details**

Marieta Georgieva1\*, Kaloyan Georgiev1 and Peter Dobromirov2

\*Address all correspondence to: marieta\_md@yahoo.com

1 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Medical University, Varna, Bulgaria

2 Medical University, Varna, Bulgaria

#### **References**


[6] Foster JA, McVey Neufeld KA. Gut-brain axis: how the microbiome influences anxi‐ ety and depression. *Trends Neurosci*. 2013;36(5):305-12. DOI: 10.1016/j.tins.2013.01.005

definition of probiotic bacteria, as well as a model for continued discovery. Bulgaria becomes famous in the world with *Lactobacillus bulgaricus* and the Bulgarian territory is still an important reservoir for isolation of natural strains of lactic acid bacteria, which after an additional selection are used as starter cultures for the production of various fermented foods and probiotic products. The biggest challenge for researchers in the field of nutrition, at present and in the future, is the study of the relationship between a certain food or a nutrient and improved health or reduced risk of various diseases. Provision of accessible and comprehen‐ sive information about the properties of functional foods is crucial for food selection by

and Peter Dobromirov2

1 Department of Pharmacology and Toxicology, Faculty of Pharmacy, Medical University,

[1] Frei R, Akdis M, O'Mahony. Prebiotics, probiotics, synbiotics, and the immune sys‐ tem: experimental data and clinical evidence. *Curr Opin Gastroenterol*. 2015;31(2):

[2] Johnson BR, Klaenhammer TR. Impact of genomics on the field of probiotic research: historical perspectives to modern paradigms. *Antonie Van Leeuwenhoek*. 2014;106(1):

[3] Qin J, Li R, Raes J, Arumugam M, Burgdorf KS, Manichanh C, et al. A human gut microbial gene catalogue established by metagenomic sequencing. *Nature*.

[4] Ianiro G, Bibbò S, Gasbarrini A, Cammarota G. Therapeutic modulation of gut micro‐ biota: current clinical applications and future perspectives. *Curr Drug Targets*.

[5] Masood MI, Qadir MI, Shirazi JH, Khan IU. Beneficial effects of lactic acid bacteria on human beings. *Crit Rev Microbiol*. 2011;37(1):91-8. DOI: 10.3109/1040841X.2010.536522

consumers.

**Author details**

210 Immunopathology and Immunomodulation

Varna, Bulgaria

**References**

Marieta Georgieva1\*, Kaloyan Georgiev1

2 Medical University, Varna, Bulgaria

\*Address all correspondence to: marieta\_md@yahoo.com

153-8. DOI: 10.1097/MOG.0000000000000151.

2010;464(7285):59-65. DOI: 10.1038/nature08821

2014;15(8):762-70. DOI: 10.2174/1389450115666140606111402

141-56. DOI: 10.1007/s10482-014-0171-y


epithelial cells after the colonization of germ-free rats. *Immunology*. 2005;115(4): 441-50. DOI: 10.1111/j.1365-2567.2005.02176.x


[31] Glaister JR. Factors affecting the lymphoid cells in the small intestinal epithelium of the mouse. *Int Arch Allergy Appl Immunol*. 1973;45(5):719-30.

epithelial cells after the colonization of germ-free rats. *Immunology*. 2005;115(4):

[20] Yan F, Cao H, Cover TL, Washington MK, Shi Y, Liu L, et al. Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism. *J Clin Invest*. 2011;121(6):2242-53. DOI:

[21] Kim SW, Park KY, Kim B, Kim E, Hyun CK. Lactobacillus rhamnosus GG improves insulin sensitivity and reduces adiposity in high-fat diet-fed mice through enhance‐ ment of adiponectin production. *Biochem Biophys Res Commun*. 2013;431(2):258-63.

[22] Giahi L, Aumueller E, Elmadfa I, Haslberger AG. Regulation of TLR4, p38 MAPki‐ nase, IκB and miRNAs by inactivated strains of lactobacilli in human dendritic cells.

[23] Wang S, Zhu H, Lu C, Kang Z, Luo Y, Feng L, et al. Fermented milk supplemented with probiotics and prebiotics can effectively alter the intestinal microbiota and im‐ munity of host animals. *J Dairy Sci*. 2012;95(9):4813-22. DOI: 10.3168/jds.2012-5426

[24] Granato D, Branco GF, Cruz AG, Faria JA, Shah NP. Probiotic dairy products as functional foods. *Comprehen Rev Food Sci Food Safety*. 2010;9(5):455-470. DOI: 10.1111/j.

[25] Cox AJ, Pyne DB, Saunders PU, Fricker PA. Oral administration of the probiotic Lac‐ tobacillus fermentum VRI-003 and mucosal immunity in endurance athletes. *Br J*

[26] Gleeson M, Bishop NC, Oliveira M, McCauley T, Tauler P, Lawrence C. Effects of a Lactobacillus salivarius probiotic intervention on infection, cold symptom duration and severity, and mucosal immunity in endurance athletes. *Int J Sport Nutr Exerc*

[27] Ng SC, Hart AL, Kamm MA, Stagg AJ, Knight SC. Mechanisms of action of probiot‐ ics: recent advances. *Inflamm Bowel Dis*. 2009;15(2):300-10. DOI: 10.1002/ibd.20602

[28] Henao-Mejia J, Elinav E, Jin C, Hao L, Mehal WZ, Strowig T et al. Inflammasomemediated dysbiosis regulates progression of NAFLD and obesity. *Nature*.

[29] Vujkovic-Cvijin I, Dunham RM, Iwai S, Maher MC, Albright RG, Broadhurst MJ et al. Dysbiosis of the gut microbiota is associated with HIV disease progression and tryp‐ tophan catabolism. *Sci Transl Med*. 2013;5(193):193ra91. DOI: 10.1126/scitranslmed.

[30] Gordon HA. Morphological and physiological characterization of germfree life. *Ann*

*Benef Microbes*. 2012;3(2):91-8. DOI: 10.3920/BM2011.0052

*Sports Med*. 2010;44(4):222-6. DOI: 10.1136/bjsm.2007.044628

2012;482(7384):179-85. DOI: 10.1038/nature10809

441-50. DOI: 10.1111/j.1365-2567.2005.02176.x

10.1172/JCI44031

212 Immunopathology and Immunomodulation

DOI: 10.1016/j.bbrc.2012.12.121

1541-4337.2010.00120.x

*Metab*. 2012;22(4):235-42.

*N Y Acad Sci*. 1959;78:208-20.

3006438


lation during and after pregnancy: a randomised controlled trial. *Br J Nutr*. 2009;101(11):1679-87. DOI: 10.1017/S0007114508111461


lation during and after pregnancy: a randomised controlled trial. *Br J Nutr*.

[44] Petersen ER, Claesson MH, Schmidt EG, Jensen SS, Ravn P, Olsen J, et al. Consump‐ tion of probiotics increases the effect of regulatory T cells in transfer colitis. *Inflamm*

[45] Blottière HM, de Vos WM, Ehrlich SD, Doré J. Human intestinal metagenomics: state of the art and future. *Curr Opin Microbiol*. 2013;16(3):232-9. DOI: 10.1016/j.mib.

[46] Le Chatelier E, Nielsen T, Qin J, Prifti E, Hildebrand F, Falony G, et al. Richness of human gut microbiome correlates with metabolic markers. *Nature*. 2013;500(7464):

[47] Lebeer S, Vanderleyden J, De Keersmaecker SC. Host interactions of probiotic bacte‐ rial surface molecules: comparison with commensals and pathogens. *Nat Rev Micro‐*

[48] Bron PA, van Baarlen P, Kleerebezem M. Emerging molecular insights into the inter‐ action between probiotics and the host intestinal mucosa. *Nat Rev Microbiol*.

[49] Klaenhammer TR, Kleerebezem M, Kopp MV, Rescigno M. The impact of probiotics and prebiotics on the immune system. *Nat Rev Immunol*. 2012;12(10):728-34. DOI:

[50] Yan F, Polk DB. Probiotics and immune health. *Curr Opin Gastroenterol*. 2011;27(6):

[51] Mohamadzadeh M, Pfeiler EA, Brown JB, Zadeh M, Gramarossa M, Managlia E, et al. Regulation of induced colonic inflammation by Lactobacillus acidophilus deficient in lipoteichoic acid. *Proc Natl Acad Sci U S A*. 2011;108(Suppl 1):4623-30. DOI: 10.1073/

[52] Kamada N, Seo SU, Chen GY, Núñez G. Role of the gut microbiota in immunity and inflammatory disease. *Nat Rev Immunol*. 2013;13(5):321-35. DOI: 10.1038/nri3430

[53] Rakoff-Nahoum S, Paglino J, Eslami-Varzaneh F, Edberg S, Medzhitov R. Recogni‐ tion of commensal microflora by toll-like receptors is required for intestinal homeo‐

[54] Kwon HK, Lee CG, So JS, Chae CS, Hwang JS, Sahoo A, et al. Generation of regulato‐ ry dendritic cells and CD4+Foxp3+ T cells by probiotics administration suppresses immune disorders. *Proc Natl Acad Sci U S A*. 2010;107(5):2159-64. DOI: 10.1073/pnas.

[55] Cain AM, Karpa KD. Clinical utility of probiotics in inflammatory bowel disease. *Al‐*

2009;101(11):1679-87. DOI: 10.1017/S0007114508111461

*Bowel Dis*. 2012;18(1):131-42. DOI: 10.1002/ibd.21709

*biol*. 2010;8(3):171-84. DOI: 10.1038/nrmicro2297

2011;10(1):66-78. DOI: 10.1038/nrmicro2690

496-501. DOI: 10.1097/MOG.0b013e32834baa4d

2013.06.006

214 Immunopathology and Immunomodulation

10.1038/nri3312

pnas.1005066107

0904055107

stasis. *Cell*. 2004 ;118(2):229-41.

*tern Ther Health Med*. 2011;17(1):72-9.

541-6. DOI: 10.1038/nature12506


[71] Sartor RB, Sherman PM, Mayer EA. An update on the use and investigation of probi‐ otics in health and disease. Gut. 2913;62(5):787-96. DOI: 10.1136/gutjnl-2012-302504

## **Chapter 10**
