**2. Epidemiology**

Castleman's disease (CD), from being rare, is now more commonly encountered. In the last three decades since the discovery of HIV, the incidence of MCD has progressively increased over time. The median age at presentation of MCD is 40 (21–67) years, with a male predomi‐ nance of 90%, based on a systematic review of published cases in the literature up to 2007 [10]. A younger age at presentation is noted in HIV-seropositive individuals with MCD compared to HIV-seronegative MCD [11,12].
