**1. Introduction**

The author analyzes the experience and the research projects worked out in the Dept. Cell Therapy of the University Hospital "Radium" (Inst. Cancer Research, Oslo, Norway) by the team of Prof. Gunnar Kvalheim, Prof. Jon Kyte, Prof. Jahn Nesland, the Bulgarian immunol‐ ogist M.Sc. Biol. Paula Lazarova, and the author himself, for the last several years.

The colleagues from Radium have utilized gene-transfer technology for developing vaccine therapy with dendritic cells transfected with tumour-mRNA. These vaccines are designed to combine the immunostimulatory capacity of dendritic cells with the antigen repertoire of tumour cells.

There are two approaches to the project: preclinical/experimental evaluation and clinical trials on patients.
