**6. Results**

Goldman three-mirror lens and measurements were taken of the size of the disk, the vertical and horizontal cup/disk ratios, the presence of rim notching or splinter hemorrhage, and the presence of peripapillary atrophy. Visual field testing with a Humphrey visual field analyzer (Humphrey-Zeiss, Dublin, CA, USA), Program 30-2 SITA STNADARD™ testing was carried out before surgery and at 6 and 12 months after surgery. Best-corrected visual acuity was measured at the 1-, 2-, 3-, 4-, 5-, 6-, 9-, and 12-month visits, and the logarithm of the minimum

The presence of complications was determined intraoperatively and at every postoperative visit. Hypotony was defined as an intraocular pressure of less than 4 mm Hg after surgery. A shallow anterior chamber was defined as reported by Teehasaenee and Ritch [11]. An intra‐ ocular pressure spike was defined as an intraocular pressure on the first postoperative day of

The surgery was considered as a success with an intraocular pressure between 6 and 20 mm Hg and an intraocular pressure reduction of greater than or equal to 30% without additional surgery, compared to the preoperative level with medical therapy. A failure was defined when

In case of postoperative intraocular pressure measurements of greater than 21 mm Hg in the trabculectomy group, despite all procedures including laser suture lysis, 5-fluorouracil injection, and needling, intraocular pressure-lowering medication was added. In case of complications requiring surgery or still inadequate intraocular pressure control in both groups,

**Study End.** All patients were meant to reach a 12-month follow-up, but the following were considered as endpoints: (1) the need for any further surgical procedure (except laser suture lysis, 5-fluorouracil injection, and needling); (2) an intraocular pressure of greater than 21 mm Hg on two consecutive visits; and (3) patient failure to attend scheduled visits, allowing for a margin of tolerance. If the study was ended before month 12, the last values obtained in the

The sample size was chosen to assure a power of at least 90% in detecting at least a 2 mm Hg difference between groups with a standard deviation of 2 mm Hg with a two-

Evaluation of continuous variables was achieved using the Student's *t*-test. To evaluate the difference in intraocular pressures between follow-up intervals, the paired *t*-test was used. All *t*-tests were two-tailed. Categoric variables were evaluated with the chi-square test, the Fisher exact test, or the Spearman rank correlation as appropriate. A level of P < 0.05 was accepted as statistically significant. Each potential confounding variable was screened for association with the outcome. Only those confounding variables that were statistically associated were eligible

angle of resolution (logMAR) was calculated and used for all statistical analyses.

greater than or equal to 3 mm Hg higher than the preoperative level.

an eye required further glaucoma surgery or lost visual function.

additional procedures could be performed as required.

to be incorporated into the potential final multivariate model.

trial were considered as the final data.

**5. Statistical analysis**

sided α error of 5%.

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Table 1 shows the demographics of the patients. Forty-two patients underwent trabeculotomy followed by latanoprost 0.004%, timolol XE 0.5%, and brinzolamide 1%, and 40 patients underwent trabeculectomy augmented with mitomycin C.


LogMAR : Log of the minimum angle of resolution

HFA 30-2 MD: Humphrey visual field analyzer Program 30-2 Mean deviation

Parenthesis indicates a range.

**Table 1.** Demographics of Patients

Mean baseline intraocular pressure was 27.9 ± 5.4 mm Hg in the trabeculotomy group and 28.3 ± 4.2 mm Hg in the trabeculectomy group (P = 0.7). Mean postoperative intraocular pressure was 15.1 ± 2.1 mm Hg at 3 months, 14.7 ± 2.1 mm Hg at 6 months, and 14.9 ± 2.0 mm Hg at 12 months in the trabeculotomy group, and it was 12.2 ± 1.9 mm Hg at 3 months, 12.8 ± 3.0 mm Hg at 6 months, and 13.9 ± 4.2 mm Hg at 12 months in the trabeculectomy group (Figure 1, Table 2). Mean intraocular pressure in the trabeculotomy group was significantly higher than that in the trabeculectomy group at 3 and 6 months (P < 0.0001 at 3 months; P = 0.0005 at 6 months), and there was no significant difference between the groups at 12 months (P = 0.1). At 12 months, 42 patients (100 %) in the trabeculotomy group and 37 patients (92.5 %) in the trabeculectomy group achieved an intraocular pressure of less than or equal to 20 mm Hg and a minimum of 30 percent reduction (P = 0.1) (Figure 2, Table 3).

**Figure 1.** Trabeculotomy

Trabeculotomy Augmented by Postoperative Topical Medications vs. Trabeculectomy Augmented by Mitomycin C http://dx.doi.org/10.5772/60089 97

**Figure 2.** Trabeculotomy

Mean baseline intraocular pressure was 27.9 ± 5.4 mm Hg in the trabeculotomy group and 28.3 ± 4.2 mm Hg in the trabeculectomy group (P = 0.7). Mean postoperative intraocular pressure was 15.1 ± 2.1 mm Hg at 3 months, 14.7 ± 2.1 mm Hg at 6 months, and 14.9 ± 2.0 mm Hg at 12 months in the trabeculotomy group, and it was 12.2 ± 1.9 mm Hg at 3 months, 12.8 ± 3.0 mm Hg at 6 months, and 13.9 ± 4.2 mm Hg at 12 months in the trabeculectomy group (Figure 1, Table 2). Mean intraocular pressure in the trabeculotomy group was significantly higher than that in the trabeculectomy group at 3 and 6 months (P < 0.0001 at 3 months; P = 0.0005 at 6 months), and there was no significant difference between the groups at 12 months (P = 0.1). At 12 months, 42 patients (100 %) in the trabeculotomy group and 37 patients (92.5 %) in the trabeculectomy group achieved an intraocular pressure of less than or equal to 20 mm Hg and

a minimum of 30 percent reduction (P = 0.1) (Figure 2, Table 3).

**Figure 1.** Trabeculotomy

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Parenthesis indicates a range.

**Table 2.** Intraocular pressure change


**Table 3.** Surgical outcome at 12 months
