**5. Aim and purpose of the study**

airways obstruction. The underlying mechanism is an increase in mucus secreting glands and alterations in the characteristics of the mucus itself [1]. Airway inflammation is present, and

Subjects with chronic bronchitis may also have symptoms such as dyspnea, chest tightness, and wheezing, and there is thus a considerable overlap in symptoms between allergic asthma, nonallergic asthma, and bronchitis [1]. Biological contamination through the presence of

Several studies have shown associations between chronic airflow obstructions as measured by spirometry (particularly FEV1) and organic dust exposures in industrial and agricultural

endotoxin and β-glucan can be incriminated in the pathogenesis of bronchitis [1].

occupational populations [1, 19]. Endotoxin exposure may play an important role.

**4.5. Hypersensitivity Pneumonitis (HP) or Extrinsic Allergic Alveolitis (EAA) [1, 2, 20]**

The disease, also known as "farmers lung" or "pigeon breeder's lung, " is one of the most severe diseases induced by fungi and thermophilic actinomycetes (spore-forming bacteria) exposure. The clinical aspect of HP is represented by severe pulmonary disease with pneu‐ monia-like fever, cough, tightness of chest, shortness of breath, inflammation of pulmonary parenchyma, and development of pulmonary granulomas. HP is very similar to organic dust

The disease is similar to influenza and is characterized by symptoms like acute fever, dry cough, dyspnea, chest tightness, headache, shivering, malaise, fatigue, and muscle and joint

In the 1988s, the concept of "sick building syndrome" (SBS) was established by the WHO [1, 3, 21, 22]. The label sick building syndrome (SBS) can be applied when the inhabitants or occupants of different indoor spaces develop acute health problems or discomfort inside the rooms. The exposed people have the following symptoms: eye, nose, and throat irritation and dryness; itching and dryness of skin and eyes; dry cough; nausea; vomiting; headache; difficulty in concentration; fatigue; etc. The symptoms disappear after cessation of the

pains. ODTS is a nonallergic neutrophil-mediated airway inflammation [1].

This disease can be induced by exposure to the biological indoor air pollutants.

an increased number of neutrophils can be observed [1].

**4.4. Chronic airflow obstruction**

494 Current Air Quality Issues

toxic syndrome (ODTS).

**4.7. Atopic allergic dermatitis**

**4.8. Sick building syndrome**

exposure.

**4.6. Organic Dust Toxic Syndrome (ODTS)**

The aim of the study was to assess indoor air contamination from the point of view of bacteriological and fungal contamination of different indoor spaces like houses, schools, offices, archives, and spaces with commercial destinations [23-25].
