**9. Conclusion**

HIV host reservoir of latently infected cells stands as the barrier to a successful longed-for cure that would free HIV-positive patients from a lifetime of taking antiretroviral drugs. Antire‐ trovirals known to protect uninfected cells reduce the viral load and stave off full-blown AIDS. However, they do not eliminate the HIV reservoir in the host. Though the virus is not com‐ pletely eradicated in EC, the reservoir could not replicate, so low viral load is recorded and antiretrovirals are unnecessary. OS however has been implicated in HIV replication and disease progression; so it can be used as a surveillance tool. The chapter presents oxidative stress and redox regulation of controllers of HIV infection as a means to achieve a functional cure. Therefore, ROS should be seen as a viable strategy to achieving HIV functional cure.
