*11.2.3.3. Sodium Dodecyl Sulphate (SDS)*

Sodium dodecyl sulphate (SDS), also called sodium lauril sulphate (SLS) [270, 271], are sulphated (negatively charged) surfactants that denature membrane proteins of pathogens and cells. SDS *in vitro* and in animal models have inhibitory activity against HIV-1 and HSV [272], promoting the reduction of adsorption of the HIV viral envelope glycoproteins in the mem‐ brane of the target cell [273]. In the form of a thermoreversible gel acts as a physical barrier and as a denaturing agent of the viral envelope glycoproteins [272, 273]. In similarity with nonoxynol 9, its long time application can cause non-specific damage to the vaginal epithelium cells, uterine and cervical tissue.
