Contents

#### **Preface XI**


Chapter 5 **Lipids and Lipoproteins in Alzheimer's Disease 99** Sophie Stukas, Iva Kulic, Shahab Zareyan and Cheryl L. Wellington


#### **Section 4 Clinical Aspects 295**


## Preface

Chapter 6 **Free Cholesterol — A Double-Edge Sword in**

**and Non-Sterol Isoprenoids 167**

Chapter 8 **Recent Progress in the Identification of Non-Invasive**

Chapter 9 **New Frontiers in Alzheimer's Disease Diagnosis 257**

Chapter 11 **Gait Pathway in Subcortical Vascular Dementia and in**

Chapter 12 **The Alzheimer's Patient in the Emergency Department —**

Chapter 13 **Uncontrolled Sexual Behaviour in Dementia 353** Susan van Hooren and Wim Waterink

Chapter 7 **The Mevalonate Pathway in Alzheimer's Disease — Cholesterol**

Amany Mohamed, Kevan Smith and Elena Posse de Chaves

Franc Llorens, Sabine Nuhn, Christoph Peter, Inga Zerr and

Chapter 10 **Genetic, Biochemical and Histopathological Aspects of Familiar**

**Biomarkers to Support the Diagnosis of Alzheimer's Disease in Clinical Practice and to Assist Human Clinical Trials 225** Francois Bernier, Pavan Kumar, Yoshiaki Sato and Yoshiya Oda

Genaro Gabriel Ortiz, Fermín P. Pacheco-Moisés, Erika D. González-Renovato, Luis Figuera, Miguel A. Macías-Islas, Mario Mireles-Ramírez, L. Javier Flores-Alvarado, Angélica Sánchez-López, Dhea G. Nuño-Penilla, Irma E. Velázquez- Brizuela, Juan P. Sánchez-Luna

Rita Moretti, Arianna Sartori, Beatrice Baso and Silvia Gazzin

De Breucker Sandra, Pepersack Thierry and Bier Jean-Christophe

**Alzheimer Disease 141** José C. Fernández-Checa

**Section 3 Biomarkers 223**

**VI** Contents

Katharina Stoeck

**Alzheimer's Disease 297**

and Alfredo Célis de la Rosa

**Alzheimer's Disease 325**

**Specificities of Care 339**

**Section 4 Clinical Aspects 295**

This book addresses many facets of Alzheimer´s disease, from epidemiology and clinical management of the patients to new approaches to understand the disease pathology. Cur‐ rently discussed pathways are highlighted and discussed. The collection covers actual topics of interest for basic researchers and clinicians and provides insights in the complex prob‐ lems in Alzheimer´s disease.

#### **Inga Zerr, MD**

Clinical Dementia Center Department of Neurology University Medical School Georg August University Göttingen Germany

**Epidemiology and Molecular Pathology**
