**Meet the editors**

Associate Professor Omboon Vallisuta received her B.S. in Pharmacy in 1974 from Mahidol University, Thailand, and her Ph.D. in Phytochemistry in 1982 from The University of Queensland, Australia. Currently, she is a professor in the department of Pharmacognosy, Faculty of Pharmacy, Mahidol University, Thailand. Her area of research interests includes traditional medicine, health

products and preventive medicine. She has published 40 scientific papers in international journals and also invited speakers to several countries in Asia, Europe and Middle East.

Professor Suleiman Olimat received his B.S in Pharmacy in 1980 from Aristotelian University, Greece, and his Ph.D. in Natural Products Chemistry in 1986 from The University of Pittsburgh, USA. Currently, he is a professor in the department of Pharmaceutical Sciences, Faculty of Pharmacy, The University of Jordan, Jordan. Prof. Olimat's interests are isolation and identification

of the active principles of medicinal plant, with focus on alkaloids. He has published more than 75 scientific papers in highly respected peer-reviewed journals. Prof. Olimat wrote a book "Chemistry of Natural Products, ALKALOIDS" in Arabic.

## Contents

**Preface XI**




## Preface

Chapter 6 **Lipids and Liposomes in the Enhancement of Health and**

Chapter 7 **The Small Molecule Inhibitor of Protein Kinase Revolution for the Treatment of Rheumatoid Arthritis 163**

**Section 4 Management and Development of Drugs Against Infectious**

Chapter 8 **Current Management and Novel Therapeutic Strategies to**

Chapter 9 **Targeting Bacterial Persistence to Develop Therapeutics**

Elizabeth Hong-Geller and Sofiya N. Micheva-Viteva

Chapter 10 **Assay Validation in High Throughput Screening – from Concept**

Sergio C. Chai, Asli N. Goktug and Taosheng Chen

Chapter 11 **Structural Analogy — Direct Similarity Versus Topographical**

Chapter 13 **Intranasal Drug Administration — An Attractive Delivery Route**

Degenhard Marx, Gerallt Williams and Matthias Birkhoff

Adriana Ceci, Viviana Giannuzzi, Donato Bonifazi, Mariagrazia Felisi,

Hrvoje Roguljic, Sonja Sarcevic, Robert Smolic, Nikola Raguz Lucic,

**Combat Chronic Delta Hepatitis 183**

Aleksandar Vcev and Martina Smolic

**Against Infectious Disease 201**

**Treatment of Disease 131** Simon A. Young and Terry K. Smith

Charles J. Malemud

**Section 5 Advanced Methodology 219**

**to Application 221**

**Complementarity 241**

**for Some Drugs 299**

Paweł Kafarski and Magdalena Lipok

Chapter 12 **Clinical Trials in Paediatrics — Regulatory and Methodological Aspects 271**

Fedele Bonifazi and Lucia Ruggieri

**Diseases 181**

**VI** Contents

It is very important for scientists all over the globe to enhance drug discovery research for better human health. This book demonstrates that various expertise are essential for drug discovery including synthetic or natural drugs, clinical pharmacology, receptor identifica‐ tion, drug metabolism, pharmacodynamic and pharmacokinetic research.

The following 5 sections cover diverse chapter topics in drug discovery. Section 1 points that natural products are important sources for drug development. Cancer is one of the major challenges facing mankind in the 21st century and Section 2 deals with in vitro models and clinical application in cancer research. Section 3 involves utilisation of small molecules and receptors for the improvements of health and better treatments. Section 4 deals with the management and development of drugs against hepatitis D and persistent infectious diseas‐ es. Finally, Section 5 offers certain advanced methodology in Drug Discovery, e.g. assay val‐ idation in high throughput screening, minor changes to the chemical structure of chosen metabolite, proposed methods for conducting paediatric trials and intranasal vaccination.

As editors of this book, we are grateful to all the leading researchers who have devoted their time to write the chapters in this book. They have demonstrated the scientific spirit required for a successful book project. We hope the readers will enjoy the chapters as much as we did.

> Editor **Dr. Omboon Vallisuta** Department of Pharmacognosy Faculty of Pharmacy Mahidol University Bangkok, THAILAND

Co-Editor **Professor Suleiman Olimat** Department of Pharmaceutical Sciences Faculty of Pharmacy The University of Jordan Amman, JORDAN
