**1. Introduction**

Neutrophil cells: were discovered by Elie Metchnikoff as an inflammatory immune response to rose thorns inserted in starfish larvae [1].

Neutrophils are a major type of white blood cell (WBC), and they represent about 45%-70% of all WBC. Neutrophils can also be referred to as poly-morphonucleat leucocytes or granulo‐ cytes, as their cytoplasm contains granules, which contains glycogen and antibacterial substances [2]. Neutrophils are synthesized and produced by hematopoietic stem cells in bone marrow. It takes 10 – 14 days to produce mature neutrophils. Neutrophils were first thought to have a short viability period of only 6-10 hours [2, 3], but in the late 1990s, it was that neutrophils may survive much longer. In addition, recent evidence has suggested that neutrophils may produce anti-inflammatory molecules and may promote the resolution of inflammation [4]. Moreover, it has been found that during inflammation or infection, neutro‐ phils will migrate to the inflamed tissues, phagocytosis and remain active at site for about 2-6 days [2, 4, 5].
