Preface

Chapter 7 **The Preventive and Therapeutic Effect of Caloric Restriction Therapy on Type 2 Diabetes Mellitus 185**

Chapter 8 **Current Recommendations for Surgical Treatment of**

Chapter 9 **The Involvement of Environmental Endocrine-Disrupting**

Carmen Purdel, Mihaela Ilie and Denisa Margina

Chapter 11 **Incretin System in the Pathogenesis of Type 2 Diabetes and the**

Chapter 12 **Anti-Obesity Effects of Androgens, Dehydroepiandrosterone**

Ayse Nur Torun and Derun Taner Ertugrul

**(DHEA) and Testosterone 295**

Morita and Tatsuo Ishizuka

**Diabetes 195**

**VI** Contents

Chapter 10 **Statins in Type 2 Diabetes 251** Kazuko Masuo

**Diabetes 271**

Shuhang Xu, Guofang Chen, Li Chunrui and Chao Liu

Anca Elena Sirbu, Aura Reghina, Carmen Barbu and Simona Fica

**Chemicals in Type 2 Diabetes Mellitus Development 219**

**Role of Incretin Based Therapies in the Management of Type 2**

Kazuo Kajita, Ichiro Mori, Masahiro , Takahide Ikeda, Hiroyuki

Obesity and type 2 diabetes are increasing worldwide problems. In this book we reviewed factors that contribute to glucose homeostasis and the pathogenesis of Type 2 diabetes. In addition the book addresses current strategies for treatment of Type 2 Diabetes. It is well accepted that obesity is strongly associated with the development of disease including Type 2 diabetes. In this book, chapters investigate the consequences of weight loss by calorie re‐ striction and by gastric by-pass surgery. The rapid normalization in glucose homeostasis for diabetics after bariatric surgery suggests that remission may be due to mechanisms involv‐ ing the surgical technique, not just weight loss. This book also addresses the use of statins, incretins and androgen therapy for type 2 diabetics. This is increasingly important since car‐ diovascular disease is a major complication for type 2 diabetes.

> **Dr. Colleen Croniger** Associate Professor Co-Director Case MMPC Department of Nutrition Case Western Reserve University

> > USA

**Glucose Homeostasis and Diabetes**
