**1. Introduction**

It is only in recent years that the attention was drawn on the important role of the kidney in glucose homeostasis. Nevertheless, along with the liver, the kidney has an important role in ensuring the energy needs during fasting periods. This organ has a vital role in absorbing the entire quantity of the filtered glucose [1]. Having a glomerular filtration rate of 180 liters per day, it filters approximately 180 grams of glucose per day, bringing its contribution in maintaining normal fasting plasma glucose (FPG) levels [2]. The reabsorption of glucose is ensured by the sodium-glucose cotransporter (SGLT) 2, responsible for the reabsorption of 90% of glucose, and SGLT1, that reabsorbs the remaining glucose [3].

Despite the large amount of data regarding the implication of the kidneys in glucose homeo‐ stasis, this organ is often overlooked as a key player in glucose metabolism. But the awareness of the renal mechanisms of glucose control is likely to increase due to the development of new types of glucose-lowering drugs that target this metabolic pathway [4].
