**14. Conclusions**

The term of diabetes mellitus includes a group of some metabolic disorders characterized by hyperglycemia with secondary damage to multiple organ systems such as end–stage renal disease, lower extremities amputations, and adult blindness. The way to ameliorate this crucial situation is to obtain better drugs for an early treatment of the patients. The clinical trials, is so far, the best procedure to offer more efficient treatments to the increasing diabetic popula‐ tion, thanks to the procedures of clinical trials [24, 25].

### **Acknowledgements**

We thank Mrs. Esperanza Velasco Rodríguez for help in the English translation. Financial sources: Department of Medicine. FIBAO ("Foundation of Basic Investigation Alejandro Otero"); and of course, to our patients for the altruistic and caring participation in the studies.
