**5. The differences among various forms of CR**

Nowadays, the regime of CR in various studies is still not uniform. This causes imparity of CR effect. A systematic review published in 2004 showed that a very low calorie diet was associ‐ ated with the most weight loss after 12 months in one small study with beneficial effects on asthma. There was no evidence that low carbohydrate diets were associated with greater longterm weight loss than low calorie diets. Nevertheless, they were associated with greater lowering of fasting plasma glucose and HbA1c than low calorie diets, with more adverse events, such as increasing risk of arhythmia, osteoporosis or kidney stones [28]. Until now, there are few evidences from large-scale follow-up studies to clarify the differences among various CR forms.
