**Preface XIII**



Contents VII

Chapter 21 **Role of Lysosomal Enzymes in** 

Chapter 22 **Physiological and Biomechanical** 

Chapter 23 **Mesothalamic Dopaminergic Activity:** 

Chapter 24 **Pathophysiology of Non-Dopaminergic** 

Nirmal Bhide and Christopher Bishop

Daniele Q. M. Madureira

Ruiping Xia

**Parkinson's Disease: Lesson from Gaucher's Disease 459** 

**Implications in Sleep Alterations in Parkinson's Disease 507**

Tommaso Beccari, Chiara Balducci, Silvia Paciotti, Emanuele Persichetti, Davide Chiasserini, Anna Castrioto,

Nicola Tambasco, Aroldo Rossi, Paolo Calabresi, Veronica Pagliardini, Bruno Bembi and Lucilla Parnetti

**Analyses of Rigidity in Parkinson's Disease 485**

**Monoamine Systems in Parkinson's Disease: Implications for Mood Dysfunction 527** 



Chapter 24 **Pathophysiology of Non-Dopaminergic Monoamine Systems in Parkinson's Disease: Implications for Mood Dysfunction 527**  Nirmal Bhide and Christopher Bishop

VI Contents

Chapter 10 **The Hsp70 Chaperone System in Parkinson's Disease 221** Adahir Labrador-Garrido, Carlos W. Bertoncini and

> **Major Component in Parkinson's Disease 247** Patricia Szot, Allyn Franklin and Murray A. Raskind

**Parkinson's Disease: A Therapeutic Target 273**

Michel Khrestchatisky, Max de Reggi and Bouchra Gharib

**Complex I Syndrome in Parkinson´s Disease 317**

Kazuhiro Imamura, Toshiharu Nagatsu and Makoto Sawada

**Serotonin and Dopamine in Parkinson's Disease 405** Janet Best, Grant Oakley, Michael Reed and H. Frederik Nijhout

**Release in the Subthalamic Nucleus: Implications for Parkinson's Disease Treatment Strategies 421** Ben Ampe, Anissa El Arfani, Yvette Michotte and

**System to the Pathogenesis of Parkinson's Disease 433**  Kaoru Takakusaki, Kazuhiro Obara and Toshikatsu Okumura

**Biothiols, and L-Dopa Therapy in Parkinson's Disease 349**

Mhamad Abou-Hamdan, Emilie Cornille,

**Alterations in Parkinson's Disease 293**

Elena Filatova, Maria Shadrina, Petr Slominsky and Svetlana Limborska

Laura B. Valdez, Manuel J. Bandez, Ana Navarro and Alberto Boveris

**Process in Parkinson's Disease 329** Hirohide Sawada, Hiromi Suzuki, Kenji Ono,

Dorszewska Jolanta and Kozubski Wojciech

**Regulation in Parkinson's Disease 373** Lynda J. Peterson and Patrick M. Flood

Chapter 18 **Mathematical Models: Interactions Between**

Chapter 19 **Dopaminergic Control of the Neurotransmitter** 

Chapter 20 **Possible Contribution of the Basal Ganglia Brainstem** 

Chapter 16 **Oxidative DNA Damage and the Level of** 

Chapter 14 **Brain Mitochondrial Dysfunction and**

Chapter 15 **Role of Microglia in Inflammatory** 

Chapter 17 **Inflammatory Responses and** 

Sophie Sarre

Cintia Roodveldt

Chapter 12 **The Energy Crisis in** 

Chapter 13 **Analysis of Transcriptome** 

Chapter 11 **The Noradrenergic System is a** 

Preface

this information.

Parkinson's disease is a complex neurological condition which is quite disabling and interfering with one's activities of daily life. The exact etiology of Parkinson's disease remains unknown. Currently it is believed that Parkinson's disease occurs due to interaction of environmental and genetic factors. Recently, there have been many significant developments in understanding the genetic mechanisms involved in Parkinson's disease. This book not only provides a good review of the genetics of Parkinson's disease but also gives a detail of other molecular pathways involved in the

A great focus has been given to pathophysiology of Parkinson's disease, role of basal ganglia and other parts of brain involved in Parkinson's disease. Every effort has been made to present correct and up to date information in this book, but medicine is a field with ongoing research and development, therefore readers may use other sources if the content of this book is found to be insufficient. Information presented in this book is considered generally accepted practice; however the authors, editor, and publisher are not responsible for any errors, omissions, or consequences from the application of

Parkinson's Clinic of Eastern Toronto & Movement Disorders Center, Toronto,

**Dr. Abdul Qayyum Rana** 

Canada

pathological process responsible for causation of Parkinson's disease.
