**6. References**


**22** 

*Turkey* 

**Histopatological Effect Characteristics of** 

*2Cumhuriyet University, Faculty of Science, Department of Chemistry Sivas,* 

When a synthetic material is placed within the human body, tissue reacts towards the implant in a variety of ways depending on the material type. The mechanism of tissue interaction (if any) depends on the tissue response to the implant surface. In general, there are three terms in which a biomaterial may be described in or classified into representing the

Biomaterials are often used and/or adapted for a medical application, thus comprises whole or part of living structures or biomedical devices which performs, augments, or replaces biological functions. Biomaterials are used in dental and surgical applications, in controlled drug delivery applications. A biomaterial may be an autograft, an allograft or a xenograft

Biomaterials are mostly polymers produced by monomers, and are used in artificial organ production in contemporary medicine. They are prepared by the polymerization reaction of

In several previous studies, we investigated whether acrylamide, methacrylamide, Nisopropylacrylamide, acrylic acid, 2-hydroxyethyl methacrylate, 1-vinyl-2-pyrrolidone and ethylene glycol had cytotoxic effects and induced apoptosis or not in spinal cord. Immunolocalization of glial fibrillary acidic protein (GFAP) was also determined, and it was evaluated by using semi-quantitative morphometrical techniques. The cytotoxicity of

Acrylic acid had the most cytotoxic effect when compared to the methacrylamide and the ethylene glycol groups. GFAP immunoreactivity was found to be rather stronger in the methacrylamide than the other monomers application groups. The methacrylamide, acrylic acid, N-vynil pyrrolidine, acrylamide, N-isopropylacrylamide and 2-hydroxyethyl methacrylate application groups had TUNEL positive cells when compared to the other groups. While some monomers used in biomaterial production seemed not to affect the cell viability and GFAP immunoreactivity, some other monomers had adverse effects on those features. This in turn may contribute to the pathological changes associated to the

tissues responses. These are bioinert, bioresorbable, and bioactive.

monomers on cultured fibroblastic cell lines was also examined *in vitro*.

**1. Introduction** 

used as a transplant material.

certain monomers.

monomer type.

**Polymeric Biomaterial Production** 

Serpil Ünver Saraydin1 and Dursun Saraydin2 *1Cumhuriyet University, Faculty of Medicine, Department of* 

*Histology and Embryology Sivas,* 

**Various Biomaterials and Monomers Used in** 

