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**9** 

*China* 

**Research on Mg-Zn-Ca Alloy as** 

*1National Engineering Laboratory for Carbon Fiber Technology, Institute of Coal Chemistry, Chinese Academy of Sciences* 

*2School of Materials Science and Engineering, Harbin Institute of Technology* 

Magnesium and magnesium alloys are light metals, which characterized a low density, high specific strength and strong specific stiffness. The fracture toughness of magnesium is greater than that of ceramic biomaterials such as hydroxyapatite. The Young's elastic modulus and compressive yield strength of magnesium are closer to those of cortical bone. Especially, Mg2+ is present in large amount in the human body and involved in many metabolic reactions and biological mechanisms. The human body usually contains approximately 35g per 70kg body weight and the human body's daily demand for Mg is about 350 mg/day. Due to the excellent biomechanical properties and biocompatibility, magnesium alloys used to be introduced as implants into orthopedic and trauma surgery in recently years [1~3].Various magnesium alloys have been investigated as biodegradable materials and some of them have been shown good biocompatibility. For example, AZ31, AZ91, WE43, LAE442, Mg-Ca and Mg-Zn have been investigated for bone implant application [4~8]. It has been shown that magnesium enhances osteogenesis response and increases newly formed bone. However, some magnesium alloys containing aluminum or heavy metal elements which have latent toxic effects on the human body. Thus, several problems such as inadequate strength, rapid corrosion and toxic ions must be solved before

It is well known that pure magnesium has poor mechanical properties and the mechanical properties of magnesium can be effectively improved by the appropriate selection of alloying elements [1]. But, based on the aforementioned considerations, the range of alloying elements used in the degradable magnesium alloys is rather limited, Zn, Mn, Ca and perhaps a very small amount of low toxicity RE can be tolerated in the human body and can also be retard the biodegradation. Therefore, Mg-Ca binary alloys attract attention of researchers because Ca is an important element of human bones. The mechanical properties and biocompatibility of Mg-Ca binary alloy can be adjusted by controlling the Ca content and processing treatment. However, an inadequate mechanical properties as well as lower corrosion resistances of Mg-Ca binary alloys are the biggest drawback of these alloys [7][8]. Fortunately, in latest recent years, Mg-Zn system is paid more attention because Zn is one of abundant nutritional elements in human body [9] [10]. Additionally, it is a great potential

**1. Introduction** 

this unique metal is widely used in biomedical fields.

**Degradable Biomaterial** 

B.P. Zhang1,2, Y. Wang2 and L. Geng2

porcine heart valve cusps and walls. *Journal of Biomedical Materials Research Part B: Applied Biomaterials*, Vol. 53, pp. 18-27

