**5. Material science for patients in the near future**

Biomaterials have had a major impact on the regenerative medicine and patient care for improving the quality of lives of human.

We have been challenging to be able to develop bioabsorbable materials, harmonized with living body, especially bone remodelling, using an innovative supersonic and acid-etching technology (Akazawa et al. 2010). Implanted biomaterials first contact to body fluid and cells. Human cells never live in dry condition. Generally, organ and tissue have interconnected porous structure for dynamic flow of body fluid. Material walls inhibit the body fluid permeation and the cell invasion. Therefore, we focused on the permeability of body fluid into the bulk of materials and the biomimetic structure for the living and working cells (Murata et al., 2007). Body fluid can permeate into collagenous materials such as DDM and DBM. Novel DDM material contains native growth factors, and adsorbs several proteins derived from body fluid. In addition, DDM with RGD sequences supports mesenchymal cell adhesion as anchorage matrix.

Most importantly, material scientists, engineers, and doctors must work together and cooperate as professionals for the development of functional materials and for the present and future of all patients.
