**Adipokines, TRH and Cells**

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**Chapter 6**

**Adipokines Involved in Macrophage Recruitment**

Recent studies have reported adipose tissue as a crucial site for the generation of inflammatory responses and mediators in metabolic syndrome. In addition to the intrinsic properties of adipocytes in energy storage and metabolic homeostasis, adipose tissue serves as a key area

An important feature of inflammation is recruitment of immune cells such as neutrophils, eosinophils, and macrophages. Macrophage infiltration of adipose tissue in obese conditions has been studied in both mice and humans. It has been suggested that expanding adipocytes or neighboring pre-adipocytes could start to produce chemotactic signals inducing to macro‐ phage recruitment, and this event is linked to systemic inflammation and insulin resistance. In this chapter, we describe several chemotactic factors that have been implicated in the

*2.1.1. Adipose tissue as a site of inflammation: expansion of adipose tissue induces an inflammatory*

Adipose tissue is connective tissue composed primarily of adipocytes. The highest percentage of cells within adipose tissue is adipocytes; other cell types present in adipose tissue are

> © 2014 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

for the interaction of adipocytes with other factors of the immune system.

recruitment of inflammatory monocytes and macrophages into adipose tissue.

Dayea Kim, Jong Hyuk Yoon, Jaeyoon Kim and

Additional information is available at the end of the chapter

Sung Ho Ryu

**1. Introduction**

**2. Body**

**2.1. Adipose tissue inflammation**

*response that contributes to metabolic disorders*

*2.1.1.1. Composition and function of adipose tissue*

http://dx.doi.org/10.5772/57558
