**5. Conclusion and recommendations**

Erectile dysfunction is an increasing global the incidence. ED is also indicative of more serious cardiovascular, psychoactive disorders. Therapeutic interventions that are successful in treating ED may be effective in treating the early stages of conditions that include atheroscle‐ rosis, angina, plaque rupture and diabetic angiopathy. One common pathological denomina‐ tor in both CVD and ED is oxidative stress, that is, the overproduction of ROS, in particular, O2- and H2O2.Thus there is direct relationship between oxidative stress, sexual impotency and psychoactive mechanisms that alters nitrogen oxide inhibition mechanisms significantly as stated above. Therefore it is necessary to evaluate potential of natural herbs/ extracts to correct disorders and disabilities evolved in the manifestation of ED. An ideal medicinal plant extract and or natural product will achieve biochemical, physiological, pharmacological responses on erectile dysfunction. However, because of the synergic or antagonistic effects of the contents of the natural plants, herbs or their extract, it would be a worthy to investigate on their bioavailability and properties in order to maximise their use. Moreover, further investigations in the clinical setting and qualify for clinical trials in humans are warranted.
