**4. Conclusion**

**Sources Morphological parts Comments References**

*Arachishypogaea* Plant parts, aqueous extract Hypolipidemic activity at 175

"Ata-Ofa' (polyherbal tea) Leaves, methanolic extract Hypolipidemic activity at 50

*Xylopiaaethiopica* Seed, methanolic extract Hypolipidemic activity at 250

*Parinaripolyandra* Fruit, ethanolic extract Hypolipidemic activity at

*Spondiamombia* Aqueous leave extract Lipid lowering effect at the

*Bauhiniathoningii* Aqueous crude extract Hypoglycemic and lipidemic

*Cajanuscajan* Methanolic leaf extract Antioxidant and

*Melantherascandens* Ethanolic leaf extract Antidiabetic and

*Jatrophatanjorensis* Methanolic leaf extract Serum lipid profile and

*Ricinuscommunis* Aqueous root extract Hypoglycaemic potential, lipid

**Table 3.** Medicinal plants investigated in Nigeria for use as Antihypolipidemic agent

methanolic extract

rhizomes

Telfairia occidentalis Plant parts,

248 Antioxidant-Antidiabetic Agents and Human Health

*Curcuma* longa methanol extract of the

*Momordicacharantia* Linn Methanolic extract of the fruits

*Morindamorindoides* Root bark, methanolic extract Hypolipidemic activity Olukunle *et al*., 2012

mg/kg

mg/kg

mg/kg

mg/kg

mg/kg

mg/kg

effecte

ranges

500mg/kg

These plants have been identified, authenticated and investigated from Nigeria flora against hyperlipidemia, using pharmacological validated animal models. They all have levels and with some levels of increase in LDL, TC, TG and decrease in HDL. Furthermore, there has been recent interest on the research towards hyperlipidemia due to its obvious relationship with

*Crotonzambesicus* Ethanolic leaf extract Lipid lowering effect Ofusori *et al*, 2012.

50-250 mg/kg

hypoglycemic and hypolipidemic acitivity 100

Anti-Diabetic and Hypolipidemic Effects at the doses of 200, 400 and 600

doses of 250, 500and 750

hypolipidemic activity at the dose of 200 mg/kg

phytochemical composition at 100, 200 and 500mg/kg dose

hypolipidemic activities at the doses of 37, 74 &111 mg/kg

profile effects At a dose of

Bilbis *et al*., 2002

Atawodi, 2001

Nwozo *et al*., 2011

Abolaji *et al*., 2007

Nwozo *et al*, 2009.

Igwe *et al*, 2008

2012.

Kolawole and Ayankunle,

Ojezele and Abatan, 2011.

Akinloye and Solanke 2011.

Oluwole *et al,* 2011.

Akpan *et al*, 2012.

Matthew *et al*, 2012.

Hypolipidemic activity Adaramoye *et al*.*,* 2007

The use of herbal or natural medicines for the treatment of various disorders has a long and extensive history. The reported plants have the potential to act as lipid-lowering agents with minimal side effects (advantage over currently synthetic drugs) and thus could find their way onto the world market as alternatives to prescribed drugs currently available to treat hyper‐ lipidermia. Most of the studies were carried out with crude extract and administered orally. The principal families in which such activity has been reported are Acanthaceae, Apiaceae, Asteraceae, Azoaceae, Combretaceae, Cucurbitaceae, Euphorbiaceae, Fabaceae, Lamiaceae, Liliaceae, Malvaceae, Myrtaceae, Rubiaceae, Rutaceae and Zingiberaceae, Finally, all the plant species appear to be promising as hypolipidemic agents with activity mediated through various mechanisms.
