**Author details**

Devasier Bennet1 and Sanghyo Kim1,2\*

\*Address all correspondence to: samkim@gachon.ac.kr

1 Department of Bionanotechnology, Gachon University, Bokjeong-Dong, Sujeong-Gu, Seongnam-Si, Republic of Korea

2 Graduate Gachon Medical Research Institute, Gil Medical Center, Inchon, Republic of Korea

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**Chapter 9**

**Mannan as a Promising Bioactive Material for Drug**

Polysaccharides are natural, non-toxic and biodegradable polymers that cover the surface of most cells and play important roles in various biological mechanisms such as immune response, adhesion, infection and signal transduction. Investigations on the alternative treatments applied by different cultures throughout the history revealed the fact that the utilized plants and fungi were rich in bioactive polysaccharides with proven immunomodu‐ latory activity and health promoting effects in the treatment of inflammatory diseases and cancer. Hence considerable research has been directed on elucidating the biological activity

Hemicelluloses are structural polysaccharides which are the second most abundant hetero‐ polymers present in nature accounting for one third of total components available in the plants (Figure 1) [2]. Mannans and xylans are the two most important hemicelluloses and hence a lot of research is mainly focused on their value-added applications and hydrolysis [3]. Mannan is a biodegradable and bioactive polysaccharide that has been a focus of interest by various sectors due to its valuable properties. The film forming capacity and biodegradability of mannans make them an interesting alternative to the petroleum-based materials. Mannanbased films and coatings were shown to exhibit low oxygen and grease permeability and, in some cases, relatively high tensile strength [4]. There are also interesting reports on the

Mannans are linear polymers of 1,4-linked mannose residues and contain less than 5% of galactose [5]. In nature, mannan is present in four different forms, each having a β-1,4-linked backbone containing mannose (linear mannan) or a combination of glucose and mannose residues (glucomannan) and occasional side chains of α-1,6-linked galactose residues (galac‐

> © 2014 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

mechanism of these polysaccharides by structure-function analysis [1].

successful use of mannan as a bioactive material in health related applications.

**Nanocarrier Systems**

http://dx.doi.org/10.5772/58413

**1. Introduction**

Songul Yasar Yildiz and Ebru Toksoy Oner

Additional information is available at the end of the chapter

