**Meet the editors**

Craig S. Atwood, Ph.D., is an Associate Professor of Medicine at the University of Wisconsin and a Health Science Specialist with the Geriatric Research, Education and Clinical Center at the William S. Middleton Memorial Veterans Administration Hospital in Madison. Dr. Atwood completed his Ph.D. in Biochemistry from the University of Western Australia in Perth, Australia prior

to post-doctoral fellowships at the National Cancer Institute, NIH, Bethesda, and Massachusetts General Hospital, Charlestown. He held faculty positions at Harvard Medical School and Case Western Reserve University prior to his current appointment where he directs the research program of the Laboratory for Endocrinology, Aging and Disease. Dr. Atwood has broad research interests related to the endocrinology of embryogenesis, adulthood and senescence as elaborated upon in 'The Reproductive-Cell Cycle Theory of Aging'. He has published over 200 scientific articles, has served on numerous review boards and is an Editor of 20 scientific journals including the Journal of Biological Chemistry. In 2006 he received the Zenith Fellows Award from the Alzheimer's Association in recognition of his research.

Sivan Vadakkadath Meethal, M.Sc., Ph.D., is a Senior Scientist in the Department of Medicine at the University of Wisconsin-Madison, Madison, Wisconsin, USA. Dr. Vadakkadath Meethal completed his Ph.D. in Biochemistry from the University of Kerala, Trivandrum, India prior to post-doctoral fellowships at the Indian Institute of Science, Bangalore, India and University of

Wisconsin-Madison, Madison, Wisconsin, USA. Dr. Vadakkadath Meethal has research interests that focus on the endocrine and epigenetic regulation of neurogenesis, neurodegeneration, neuroregeneration, cancer and aging. He has published widely in these areas, is an editor of several scientific journals and has received numerous fellowships and awards for his research.

Contents

**Preface VII**

Hiroshi Koide

**Hematopoiesis 87**

Ma

**Section 1 Stem Cell Self-Renewal and Pluripotency 1**

Chapter 2 **Embryonic Stem Cells and Oncogenes 41**

Chapter 1 **The Role of an NFκB-STAT3 Signaling Axis in Regulating the Induction and Maintenance of the Pluripotent State 3**

**Section 2 Stem Cells as a Model System for Studing Haematopoiesis 63**

Monika Stefanska, Valerie Kouskoff and Georges Lacaud

Bo Chen, Bin Mao, Shu Huang, Ya Zhou, Kohichiro Tsuji and Feng

Chapter 4 **Human Embryonic Stem Cell-Derived Primitive and Definitive**

Chapter 5 **Generation and Maintenance of iPSCs From CD34+Cord Blood Cells on Artificial Cell Attachment Substrate 117**

Naoki Nishishita, Takako Yamamoto, Chiemi Takenaka, Marie

Chapter 3 **Embryonic Stem Cell Differentiation – A Model System to**

**Study Embryonic Haematopoiesis 65**

**Section 3 Technical Advances in the Culture and Use of Induced Pluripotent and Embryonic Stem Cells 115**

Muramatsu and Shin Kawamata

Jasmin Roya Agarwal and Elias T. Zambidis
