**5. New therapeutic approaches**

Some of side effects of therapy with VPA have been suggested by alteration the homeostasis of trace elements and antioxidants. Seriously increase membrane lipid peroxidation at the expense of protective antioxidants; this may lead to an increase in the frequency of seizures and an idiosyncratic drug effect.

Adequate trace elements and antioxidants supply is essential for normal brain functions, and is particularly important for protection against neurological disorders. To elucidate the mechanism of action such substances in the brain should result in new safe therapeutic approaches.
