**1. Introduction**

Ozone is a natural gas consisting of three oxygen atoms that has a distinctive odor. It is intrinsically hazardous over tolerable doses for living organisms. Ozone therapy is a medical therapy that a mixture of oxygen and ozone which is called medical ozone is used as a medical drug, more correctly pro-drug. Medical ozone contains less than 5% of ozone at maximum concentration where rest of it is pure medical oxygen.

The unbelievable versatility of ozone therapy is due to the cascade of ozone-derived com‐ pounds able to act on several targets leading to a multifactorial correction of various patho‐ logical states. Ozone therapy can improve well-being and delay the negative effects of aging. Aging process basicly related with oxidants and anti-oxidants balance, Advanced Glycoslation End Substances (AGEs), role of genes and immune system, relevance of telomeres and telomerase, hormones, nutrition, environmental factors and some other factors.
