*4.7.4. Tandutinib*

Tandutinib (MLN0518) is an active inhibitor of type III receptor kinases with activity against PDGF receptors alpha and beta, FLT3, and c-KIT. Its anti-angiogenic effects appear to be mediated by interruption of PDGF/PDGFR. It is currently being investigated in combination therapy with other agents against malignant glioma (Boult, Terkelsen et al. 2013).
