**Author details**

Osamu Takai1 , Maria Antoaneta Bratescu1 , Tomonaga Ueno2 and Nagahiro Saito1

1 EcoTopia Science Institute, Nagoya University, Nagoya, Japan

2 Green Mobility Collaborative Research Center, Nagoya University, Nagoya, Japan

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**Chapter 7**

**Tissue Engineering and Regenerative Medicine**

Tissue specific adult stem cells are the most hopeful cell at this moment for clinical use because it may represent Mother Natureʹs repair cells. Such cells are potentially present within all of the tissue of the body and may remain dormant until they are activated in response to tissue injury. Initially, the chemical environment at the site of any injury is very hostile. These adult stem cells, having a low oxygen requirement, appear to have the ability to survive this environment. When adequate numbers of cells have been achieved by multiplication, they are then programmed to mature and repair tissue damage of a certain magnitude. If this is the case, with the development of appropriate tissue‐specific scaffolds and the use of the optimal cell type, I believe that physicians and scientists will ultimately be able to repair or replace any tissue in the human body that is injured or damaged as a result of disease or trauma. Studies involving the use of stem cells and mature cells, in combination with genetic manipulation and determination of the efficacy cellular delivery systems and scaffoldings, should be enable rapid progression to human treatments. It is my belief that exploring the use of appropriate vehicles and cell types will ultimately lead to resolution of stroke symptoms, such as paralysis, and may help reverse symptoms associated with such central nervous system diseases as

This chapter was edited by collecting all the achievement performed in the laboratory of oral and maxillofacial surgery and it brings together the specific experiences of the scientific community in these experiences of our scientific community in this field as well as the clinical experiences of the most renowned experts in the fields from all over Nagoya University. The editors are especially proud of bringing together the leading biologists and material scientists together with dentist, plastic surgeons and surgeons of all specialities from all department of the medical school of Nagoya University. Taken together, this unique collection of worldwide

> © 2013 Ueda; licensee InTech. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use,

© 2013 Ueda; licensee InTech. This is a paper distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

distribution, and reproduction in any medium, provided the original work is properly cited.

Minoru Ueda

**1. Introduction**

Parkinsonʹs disease and Alzheimerʹs disease.

**2. Research projects**
