**Acknowledgements**

We thank to the following researchers working in our department; Mohammad Nizam Uddin, Rong Zhang, Hirohiko Suzuki, Yuta Inami, Tohru Yoshikai, Hidetoshi Sakurai and Hideaki Ishikawa. We thank Minoru Tanaka, Ikuyo Mizuguchi and Yushikazu Fujita in the Division for Medical Research Engineering, Nagoya University Graduate School of Medicine for assistance with flow cytometry, confocal microscopy and electron microscopy respectively. We also thenk to the secretary works of Nanae Oiwa. This work was supported by the GCOE program and research grant provided by the Ministry of Education, Science, Technology, Sports and Culture, Japan.

## **Author details**

Ken‐ichi Isobe, Naomi Nishio, Thanasegaran Suganya, Zhao Cheng and Sachiko Ito

Department of Immunology, Graduate School of Medicine, Nagoya University, Nagoya, Ja‐ pan
