**3. Statistics**

Significant differences for multiple independent groups of observation were identified using Kruskal-Wallis and contrasted by Mann-Whitney U-test. Significant differences for dependent

group of observation was identified using Wilcoxon´s signed rank test. Nonparamitric correlation analysis was performed by Spearman´s rank correlation test. A p-value ≤0.05 was considered to be of statistical significance.

Fig. 1. Typical western blot for MPO (Panel A), NADPH oxidas (Panel B), iNOS (Panel C), nitrotyrosine (Panel D), IL-1β (Panel E) and IL-6 (Panel F) with a band at 60 kDa, 66 kDa, 130 kDa, 47 kDa, 31 kDa and 21.5 kDa respectively, in the positive control cell lysate HL-60, cell lysate 12-354, mouse macrophage cell line RAW 264.7 and serum, and in human esophageal mucosal biopsy retrieved during endoscopy
