**6. Illness intrusiveness**

One of the important determinants of quality of life is taking part in psychologically mean‐ ingful activity. Illnesses, mostly chronic ones interfere with valued activities. Illness intrusive‐ ness is a determinant of quality of life in patients with chronic disease. Illness intrusiveness covers the disease- and treatment-induced disruptions to lifestyles, activities, and interests [43]. There is only one available study about the relationship of illness intrusiveness and CABG: our work group investigated psychosocial factors like illness intrusiveness, depression, anxiety, sleeping disorders and found an independent association with the occurrence of major adverse cardiac and cerebrovascular events (MACCE) after adjustment of biomedical factors and perioperative variables following cardiac surgery. Additionally, severity of illness intrusiveness, sleeping problems and social inhibition increased in the MACCE positive patients during the three-year period; these tendencies were not observed in the event-free group [44].
