**2. Leukocyte functional studies in patients on high-flux biocompatible hemodialysis**

Our research group has described functions of *in vivo* extravasated monocytes and neutrophils from patients on high-flux hemodialysis/hemodiafiltration and healthy subjects (Olsson et al. 2007). The objective was to study leukocyte function and specifically, to study the up-regulation of CD11b, production of hydrogen peroxide and apoptosis of *in vivo* extravasated monocytes and neutrophils at the site of an induced interstitial inflammation in patients on high-flux hemodialysis/hemodiafiltration, compared with healthy subjects. Our group has also described the concentrations of important inflammatory mediators for neutrophils (IL-8 and MMP-9/NGAL) and monocytes (MCP-1 and MIP-1α) in the peripheral circulation and at sites of interstitial inflammation in patients on high-flux hemodialysis/hemodiafiltration, compared with healthy subjects (Olsson et al. 2009).
