**Meet the editors**

Dr. Angelo Carpi is a clinical professor of medicine and Director of the Division of Male Infertility of the Department of Reproduction and Aging in the Pisa University Medical School, Pisa, Italy. He earned his M.D. and postgraduate degrees in internal medicine and nuclear medicine from the University of Pisa, as well as a diploma of qualification on peptide hormones from the Collegio Medico Giuridico-Scuola Normale Superiore and the Scuola Superiore Sant'Anna, Pisa, Italy. He is the author of about 300 publications, member of editorial boards of the international journals Biomedicine & Pharmacotherapy and Frontiers in Bioscience and organizer of 52 scientific meetings and editor of 20 books often including nephrologic aspects. Additional information at www.carpimed.it.

Professor Carlo Donadio is the clinical professor of nephrology and Director of the Laboratory of Renal Functional Evaluation and of the hemodialysis unit at Pisa University. He is also Director of the Master Course of Dialytic Treatment of Renal Failure held at the Department of Internal Medicine of Pisa University. Professor Donadio graduated as M.D. and post-graduated in internal medicine, nephrology, and nuclear medicine at Pisa University. His major research interests and clinical activities are in different nephrological topics, from the patho-physiology of renal diseases, through the validation of methods to measure renal function in man, the assessment of new serum and urinary markers of glomerular and tubular impairment, the evaluation and prevention of nephrotoxicity due to drugs and contrast media. Studies in chronic kidney disease (CKD) patients addressed the evaluation of bone turnover and parathyroid hormone, the inflammatory status, the global approach to the cardiovascular risk, the analysis of body composition and nutritional status in CKD, renal transplant recipients and maintenance hemodialysis patients. Recently, Prof. Donadio applied proteomic techniques to the study of patho-physiology of uremic syndrome and to the evaluation of depurative and inflammatory characteristics of resins, high and low-flux membranes for hemodialysis.

Professor Gianfranco Tramonti is the clinical professor of nephrology at the Department of Internal Medicine at the Pisa University Medical School, Pisa, Italy. He earned his M.D. and postgraduate degrees in internal medicine, nuclear medicine and nephrology from the University of Pisa. He also attended as visiting professor at Northwestern University of Chicago Medical School from November 1999 through October 2000, from July 2003 through November 2003 and from December 2010 through March 2011. Field of research: renal function and new markers to detect renal function, renal metabolism of low molecular weight proteins, nephrotoxicity, activity and expression of tubular cell transporters in vivo and in renal tubular cell line cultures. His research activities have produced more than 50 publications, most of which on nephrology.

Contents

**Preface IX** 

Chapter 2 **Automated Blood Volume** 

Chapter 3 **Sodium and Hemodialysis 47** 

Chapter 4 **Polyethersulfone Hollow Fiber** 

Chapter 5 **The Evolution of Biocompatibility:** 

Chapter 6 **Pulse Push/Pull Hemodialysis:** 

Merike Luman and Ivo Fridolin

Chapter 8 **Influence of Online Hemodiafiltration on** 

Kyungsoo Lee

**Part 1 Modeling, Methods and Technique 1** 

Chapter 1 **Kinetic Modeling and Adequacy of Dialysis 3** 

**Regulation During Hemodialysis 27** 

Matthew Gembala and Satish Kumar

**Membranes for Hemodialysis 65** 

Baihai Su, Shudong Sun and Changsheng Zhao

Maria Chiara Deregibus and Emanuele Gatti

**From Microinflammation to Microvesiscles 93** 

**Convective Renal Replacement Therapy 113** 

Chapter 7 **Optical Dialysis Adequacy Monitoring: Small Uremic Toxins** 

Kai Lauri, Jürgen Arund, Jana Holmar, Risto Tanner,

**Hemoglobin Level, ESA-Dosage and Serum Albumin – A Retrospective, Multicenter Analysis 161**  Roland E. Winkler, Peter Ahrenholz and Klaus Freivogel

Ciro Tetta, Stefano Maffei, Barbara Cisterna, Valentina Fonsato, Giorgio Triolo, Giuseppe Paolo Segoloni, Giovanni Camussi,

**and Contribution to UV-Absorbance Studied by HPLC 143** 

Malgorzata Debowska, Bengt Lindholm and Jacek Waniewski

Isabelle Chapdelaine, Clément Déziel and François Madore
