**4. Acknowledgement**

I want to thank my co-investigators and co-authors Stefan H Jacobson, Joachim Lundahl, Ali Moshfegh, Josefin Paulsson and Elham Dadfar. I also want to thank Titti Nieminen and Anette Bygdén-Nylander for skilful technical support. These studies were made possible by an unrestricted grant from Karolinska Institutet, Stockholm, Sweden and Terumo Europe N.V. *dedicated to well being*. The author also received financial support from the Swedish Society of Nephrology.
