**2.2.2 Hydrogen peroxide formation**

Results for hydrogen peroxide production in neutrophils and monocytes are displayed in Figures 3-6. The findings indicate the presence of a dose-response phenomenon in terms of leukocyte function at the site of interstitial inflammation in patients on high-flux hemodialysis/hemodiafiltration, which could be due to leukocyte refractoriness when encountered with an intense inflammatory stimulus. Refractoriness of leukocytes could be caused by previous priming, giving rise to an impaired response to a second activating stimulus.
