**2.3 Fibrinogene**

In the normal population, increased activity of procoagulant proteins including factor VII and fibrinogen is associated with coronary risk. Factor VII coagulant activity and markers of thrombin activation are elevated in patients with chronic renal failure and correlate positively with serum triglycerides and the acute phase reactants interleukin 6 and fibrinogen and negatively with serum albumin (Tomson, 2000). The presence of generalized endothelial dysfunction in uraemic patients is also suggested by higher plasma levels of fibrinogen, endothelin and other factors. The relationship between carotid artery intimamedia thickness and fibrinogene in hemodialysis patients without comorbidities may reflect the role of fibrinogene in early-onset atherosclerosis as one of the best-studied inflammation markers (Zumrutdal et al., 2005).
