**Role of Endoscopic Sinus Surgery in Pediatric Acute Complicated Sinusitis**

Timothy P. McEvoy, Charles A. Elmaraghy and Kris R. Jatana

Additional information is available at the end of the chapter

http://dx.doi.org/10.5772/52551

### **1. Introduction**

Sinus surgery was initially done transnasally or by a transmaxillary approach with the use of external lighting (often a headlight) and the surgeon's direct vision. Endoscopic techni‐ ques for intranasal surgery were first pioneered for adult applications and were gradually applied to pediatric sinus surgery as endoscope technology improved and smaller diameter endoscopes became available. Techniques that were developed in Europe were championed by Kennedy in the United States, with an emphasis on targeted removal of diseased tissue and preservation of normal mucosa [1, 2].

In 1989, Gross *et al.* published one of the first case series documenting functional endoscopic sinus surgery in the pediatric population. They noted that all 57 children in the series toler‐ ated the procedure well and that there were no major complications [3]. Since that time, en‐ doscopic intranasal surgical techniques in children have become commonplace for applications ranging from chronic sinusitis and nasal polyposis to the treatment of compli‐ cations of acute sinusitis as well as approaches to the skull base.

### **2. Equipment**

#### **2.1. Camera and monitors**

Initially, endoscopic sinus surgery was performed with the surgeon looking directly through the optical telescope. As digital cameras improved, the images could be magnified and viewed on a monitor allowing the surgeon better visualization as well as improving

their working room and ability to operate. In recent years, improvements in the size and rea‐ sonable cost of high-definition monitors and cameras have allowed these to become com‐ monplace in many operating rooms and clinics.

**2.3. Endoscopic surgical instruments**

avoiding disturbing normal mucosa.

**3. Pertinent sinonasal embryology**

remove bone.

of development [5].

Miniaturized versions of adult sinus surgery instruments are available from several instru‐ ment manufacturers. These instruments allow surgeons to open particular sinuses while

Role of Endoscopic Sinus Surgery in Pediatric Acute Complicated Sinusitis

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105

Another important instrument for endoscopic sinus surgery is the microdebrider. Several manufacturers have produced powered devices that can remove tissue during endoscopic sinus surgery. For example, a 4.0 and a 2.9 mm microdebrider blade can be used depend‐ ing on the size of the patient. The smaller powered instruments do tend to get clogged with bone chips more frequently. In addition, endoscopic drills exist which can precisely

During fetal development the nasal placode is noted at around four and a half weeks. The nasal cavity is then formed due to the fusion of the medial and lateral nasal proc‐ esses. The turbinates develop shortly thereafter at around 40 days [4]. Ethmoid budding is noted around 11 to 12 weeks and maxillary budding is noted around 14 to 15 weeks

The progression of sinus development was initially documented via cadaver studies, and a recent large-scale imaging study helped re-confirm these findings through non-invasive MRI scanning to evaluate the volume of the paranasal sinuses of patients with healthy si‐ nuses undergoing scans for other reasons. It was found that initial pneumatization was not‐ ed for the maxillary and ethomid sinuses at birth, for the sphenoid sinus at 9 months, and for the frontal sinus after 5 years of age. Additionally the development of the paranasal si‐

The fact the sinuses are continuing to develop as children grow becomes important in con‐ sidering the possible acute complications of sinusitis that will be discussed later in this chap‐ ter. The peak time for development of the frontal sinus and the diploic venous system is in adolescence [6], which partially explains why adolescents are the most common age group

Due the relative rarity of cases of acute complicated sinusitis in children, the exact incidence is unclear. The most frequent complications of sinusitis in children are extracranial and in‐ clude periorbital/orbital cellulitis and subperiosteal/orbital abscess. These two complications comprise up to 90 percent of complications of sinusitis in children [7]. Opthalmological eval‐ uation is critical in these cases to thoroughly assess the status of the eye. However, in the subset of patients who require inpatient admission for treatment, the incidence of intracrani‐

**4. Clinical presentation of pediatric acute complicated sinusitis**

nuses was noted to be ongoing until at least the late teen years [5].

afflicted by intracranial complications of sinusitis.

### **2.2. Endoscopes**

There are a variety of endoscopes that can be used for pediatric sinus surgery. Depending on the size of the patient, the 4.0 mm diameter endoscope (used for adult sinus procedures) provides the best field of view and resolution. If the child's anatomy is too small to accom‐ modate the 4.0 mm endoscope, a 2.7 mm diameter endoscope can be used. However, the 2.7 mm telescope is more fragile and can be easily broken if too much pressure is placed on the shaft.

Depending on the surgical application, different angled endoscopes are available to provide optimal visualization into the sinuses. The 0 degree endoscope is one of the easiest endo‐ scopes to use as it provides a straight-on view. Scopes with angled tips that allow for views of 30, 45 and 70 degrees are frequently used for endoscopic sinus surgery. During a particu‐ lar procedure, the surgeon may switch endoscopes frequently depending on which portion of the anatomy they would like to view and operate upon. The 0 degree scope is most com‐ monly used for visualizing the ethmoid and sphenoid sinuses, however angled scopes are most commonly used for viewing the maxillary and frontal sinuses. The angle of most scopes is fixed, however the scope can be turned to visualize in any direction. A scope is now available, which is a heavier than others, that allows for adjustment of the angle on a single scope. The stem of scope, which is where the light cord attaches, can be turned to fa‐ cilitate looking in other directions. In order to avoid interference of instruments used, scopes that have the light cord coming off the same side or opposite side that the scope is directed are available. Both the standard and reverse-post scopes are an important component of a surgeon's armamentarium.

**Figure 1.** Telescopes, from left to right, 0, 30, 70 degree respectively.

### **2.3. Endoscopic surgical instruments**

their working room and ability to operate. In recent years, improvements in the size and rea‐ sonable cost of high-definition monitors and cameras have allowed these to become com‐

There are a variety of endoscopes that can be used for pediatric sinus surgery. Depending on the size of the patient, the 4.0 mm diameter endoscope (used for adult sinus procedures) provides the best field of view and resolution. If the child's anatomy is too small to accom‐ modate the 4.0 mm endoscope, a 2.7 mm diameter endoscope can be used. However, the 2.7 mm telescope is more fragile and can be easily broken if too much pressure is placed on the

Depending on the surgical application, different angled endoscopes are available to provide optimal visualization into the sinuses. The 0 degree endoscope is one of the easiest endo‐ scopes to use as it provides a straight-on view. Scopes with angled tips that allow for views of 30, 45 and 70 degrees are frequently used for endoscopic sinus surgery. During a particu‐ lar procedure, the surgeon may switch endoscopes frequently depending on which portion of the anatomy they would like to view and operate upon. The 0 degree scope is most com‐ monly used for visualizing the ethmoid and sphenoid sinuses, however angled scopes are most commonly used for viewing the maxillary and frontal sinuses. The angle of most scopes is fixed, however the scope can be turned to visualize in any direction. A scope is now available, which is a heavier than others, that allows for adjustment of the angle on a single scope. The stem of scope, which is where the light cord attaches, can be turned to fa‐ cilitate looking in other directions. In order to avoid interference of instruments used, scopes that have the light cord coming off the same side or opposite side that the scope is directed are available. Both the standard and reverse-post scopes are an important component of a

monplace in many operating rooms and clinics.

**2.2. Endoscopes**

surgeon's armamentarium.

**Figure 1.** Telescopes, from left to right, 0, 30, 70 degree respectively.

shaft.

104 Endoscopy

Miniaturized versions of adult sinus surgery instruments are available from several instru‐ ment manufacturers. These instruments allow surgeons to open particular sinuses while avoiding disturbing normal mucosa.

Another important instrument for endoscopic sinus surgery is the microdebrider. Several manufacturers have produced powered devices that can remove tissue during endoscopic sinus surgery. For example, a 4.0 and a 2.9 mm microdebrider blade can be used depend‐ ing on the size of the patient. The smaller powered instruments do tend to get clogged with bone chips more frequently. In addition, endoscopic drills exist which can precisely remove bone.

### **3. Pertinent sinonasal embryology**

During fetal development the nasal placode is noted at around four and a half weeks. The nasal cavity is then formed due to the fusion of the medial and lateral nasal proc‐ esses. The turbinates develop shortly thereafter at around 40 days [4]. Ethmoid budding is noted around 11 to 12 weeks and maxillary budding is noted around 14 to 15 weeks of development [5].

The progression of sinus development was initially documented via cadaver studies, and a recent large-scale imaging study helped re-confirm these findings through non-invasive MRI scanning to evaluate the volume of the paranasal sinuses of patients with healthy si‐ nuses undergoing scans for other reasons. It was found that initial pneumatization was not‐ ed for the maxillary and ethomid sinuses at birth, for the sphenoid sinus at 9 months, and for the frontal sinus after 5 years of age. Additionally the development of the paranasal si‐ nuses was noted to be ongoing until at least the late teen years [5].

The fact the sinuses are continuing to develop as children grow becomes important in con‐ sidering the possible acute complications of sinusitis that will be discussed later in this chap‐ ter. The peak time for development of the frontal sinus and the diploic venous system is in adolescence [6], which partially explains why adolescents are the most common age group afflicted by intracranial complications of sinusitis.

### **4. Clinical presentation of pediatric acute complicated sinusitis**

Due the relative rarity of cases of acute complicated sinusitis in children, the exact incidence is unclear. The most frequent complications of sinusitis in children are extracranial and in‐ clude periorbital/orbital cellulitis and subperiosteal/orbital abscess. These two complications comprise up to 90 percent of complications of sinusitis in children [7]. Opthalmological eval‐ uation is critical in these cases to thoroughly assess the status of the eye. However, in the subset of patients who require inpatient admission for treatment, the incidence of intracrani‐ al complications has been estimated to be around 3% based on a large review of patients ad‐ mitted with sinusitis [8]. Interestingly, male patients account for 60-70% of the cases of complications of acute sinusitis [9].

**5. Role of imaging in pediatric acute complicated sinusitis**

CT scanning is the gold standard for imaging of the paranasal sinuses. Unlike for patients with chronic sinusitis for whom non-contast studies may be sufficient, children with possi‐ ble complications of acute sinusitis require contrast-enhanced studies. One drawback of CT scanning is that it does lack specificity due to mucosal changes that may be considered inci‐ dental and due to the slow resolution of edema after infections [10, 14]. Although there is a priority to avoid the radiation of a CT scan in children, it remains a crucial imaging modali‐ ty for diagnosis and management of acute complicated sinusitis. CT can often miss intracra‐ nial involvement in cases of acute complicated sinusitis up to 50% of the time. Patients 7 years and older with orbital infections have been shown to have about a 10% incidence of

Role of Endoscopic Sinus Surgery in Pediatric Acute Complicated Sinusitis

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107

Contrast-enhanced MRI scans are necessary for patients who are suspected of having intra‐ cranial complications of sinusitis. MRI is superior to CT in that it is able to delineate early cerebritis changes as well as provide further detail regarding the meninges, marrow spaces

Image guidance systems are used widely by both otolaryngologists and neurosurgeons for adult applications*.* Data regarding the utility of image guidance in children is not as abun‐ dant. However, literature reviews of the indications and safety of image guidance in pedia‐ tric sinus and skull base surgery supports its use for complex cases and cases with distorted anatomy which includes cases of acute complicated sinusitis. Additionally, there were no complications that were reported in either retrospective studies[16, 17]. Image guidance can include CT and/or MRI, however, for cases of acute complicated sinusitis, CT is the most useful for defining bony landmarks within the sinonasal cavity. MRI can certainly assist

Medical management of children with acute complicated sinusitis is mainly centered around the administration of IV antibiotics. Broad-spectrum antibiotics are chosen until culture-di‐ rected therapy can be provided. Adjunctive therapy to help reduce mucosal edema includes systemic steroids and decongestants, and topical decongestants (oxymetazaline) and topical steroids. However, there is not much literature to support the use of these agents in the set‐ ting of acute complicated sinusitis, but there is no definitive evidence that these would be harmful. Additionally, nasal saline irrigation or nasal saline spray can be helpful to clear se‐

**5.1. Computed Tomography (CT)**

concomitant intracranial involvement [15].

**5.2. Magnetic Resonance Imaging (MRI)**

**5.3. Intraoperative surgical guidance**

**6. Role of medical management**

as well as the orbital apex and cavernous sinus [10, 14].

with soft tissue landmarks when needed in complex cases.

**Figure 2.** Left periorbital cellulitis with associated subperiosteal abscess

Orbital complications and intracranial complications can present somewhat differently, but at times they can have overlapping symptoms. In addition to systemic symptoms of fever and change in energy level and nasal symptoms of congestion and purulent drainage, pa‐ tients with orbital complications such as cellulitis and abscess typically develop erythema and edema of the eyelid as well as proptosis [10]. Decreased ocular motility is also a fre‐ quent sign of orbital cellulitis and abscess with a reported incidence of approximately 35% and 80% respectively [7]. Visual acuity can be worsened, and in severe cases nonreactive pu‐ pils are noted. Complete opthalmological evaluation is an important part of the manage‐ ment of these patients with orbital complications.

Intracranial complications can present in a somewhat non-specific manner with the most frequent symptoms being fever in about 75% and headache in 67-92% of children [11-13]. Other systemic symptoms include nausea and vomiting and lethargy. Some pa‐ tients with intracranial pathology can present with extracranial complications at the same time, such as orbital cellulitis and forehead abscesses [11]. A significant number patients with intracranial complications of sinusitis (38-59%) will present with *normal* neurological exams [11, 13], which makes diagnosis more difficult and emphasizes the importance of proper imaging studies in the evaluation of these patients. Patients that present with central neurologic signs and symptoms can present with an altered level of consciousness, cranial nerve palsies, hemiparesis, new onset seizures, visual disturbances, slurred speech, and meningeal signs [7, 11-13].

Of note, patients with intracranial complications of sinusitis have a high incidence of seiz‐ ures and anticonvulsant therapy as prophylaxis should be considered for all patients with intracranial complications [13].

### **5. Role of imaging in pediatric acute complicated sinusitis**

### **5.1. Computed Tomography (CT)**

al complications has been estimated to be around 3% based on a large review of patients ad‐ mitted with sinusitis [8]. Interestingly, male patients account for 60-70% of the cases of

Orbital complications and intracranial complications can present somewhat differently, but at times they can have overlapping symptoms. In addition to systemic symptoms of fever and change in energy level and nasal symptoms of congestion and purulent drainage, pa‐ tients with orbital complications such as cellulitis and abscess typically develop erythema and edema of the eyelid as well as proptosis [10]. Decreased ocular motility is also a fre‐ quent sign of orbital cellulitis and abscess with a reported incidence of approximately 35% and 80% respectively [7]. Visual acuity can be worsened, and in severe cases nonreactive pu‐ pils are noted. Complete opthalmological evaluation is an important part of the manage‐

Intracranial complications can present in a somewhat non-specific manner with the most frequent symptoms being fever in about 75% and headache in 67-92% of children [11-13]. Other systemic symptoms include nausea and vomiting and lethargy. Some pa‐ tients with intracranial pathology can present with extracranial complications at the same time, such as orbital cellulitis and forehead abscesses [11]. A significant number patients with intracranial complications of sinusitis (38-59%) will present with *normal* neurological exams [11, 13], which makes diagnosis more difficult and emphasizes the importance of proper imaging studies in the evaluation of these patients. Patients that present with central neurologic signs and symptoms can present with an altered level of consciousness, cranial nerve palsies, hemiparesis, new onset seizures, visual disturbances,

Of note, patients with intracranial complications of sinusitis have a high incidence of seiz‐ ures and anticonvulsant therapy as prophylaxis should be considered for all patients with

complications of acute sinusitis [9].

106 Endoscopy

**Figure 2.** Left periorbital cellulitis with associated subperiosteal abscess

ment of these patients with orbital complications.

slurred speech, and meningeal signs [7, 11-13].

intracranial complications [13].

CT scanning is the gold standard for imaging of the paranasal sinuses. Unlike for patients with chronic sinusitis for whom non-contast studies may be sufficient, children with possi‐ ble complications of acute sinusitis require contrast-enhanced studies. One drawback of CT scanning is that it does lack specificity due to mucosal changes that may be considered inci‐ dental and due to the slow resolution of edema after infections [10, 14]. Although there is a priority to avoid the radiation of a CT scan in children, it remains a crucial imaging modali‐ ty for diagnosis and management of acute complicated sinusitis. CT can often miss intracra‐ nial involvement in cases of acute complicated sinusitis up to 50% of the time. Patients 7 years and older with orbital infections have been shown to have about a 10% incidence of concomitant intracranial involvement [15].

### **5.2. Magnetic Resonance Imaging (MRI)**

Contrast-enhanced MRI scans are necessary for patients who are suspected of having intra‐ cranial complications of sinusitis. MRI is superior to CT in that it is able to delineate early cerebritis changes as well as provide further detail regarding the meninges, marrow spaces as well as the orbital apex and cavernous sinus [10, 14].

#### **5.3. Intraoperative surgical guidance**

Image guidance systems are used widely by both otolaryngologists and neurosurgeons for adult applications*.* Data regarding the utility of image guidance in children is not as abun‐ dant. However, literature reviews of the indications and safety of image guidance in pedia‐ tric sinus and skull base surgery supports its use for complex cases and cases with distorted anatomy which includes cases of acute complicated sinusitis. Additionally, there were no complications that were reported in either retrospective studies[16, 17]. Image guidance can include CT and/or MRI, however, for cases of acute complicated sinusitis, CT is the most useful for defining bony landmarks within the sinonasal cavity. MRI can certainly assist with soft tissue landmarks when needed in complex cases.

### **6. Role of medical management**

Medical management of children with acute complicated sinusitis is mainly centered around the administration of IV antibiotics. Broad-spectrum antibiotics are chosen until culture-di‐ rected therapy can be provided. Adjunctive therapy to help reduce mucosal edema includes systemic steroids and decongestants, and topical decongestants (oxymetazaline) and topical steroids. However, there is not much literature to support the use of these agents in the set‐ ting of acute complicated sinusitis, but there is no definitive evidence that these would be harmful. Additionally, nasal saline irrigation or nasal saline spray can be helpful to clear se‐ cretions in the sinonasal cavity. However, the utility of topical therapies depend on the age and developmental level of each child.

### **7. Complications of acute sinusitis**

### **7.1. Periorbital and orbital cellulitis**

About 60 to 85% of orbital and periorbital infections are attributed to the paranasal sinuses [14]. Periorbital cellulitis is the most frequent complication of sinusitis in the pediatric popu‐ lation. Fortunately, most cases of periorbital cellulitis will respond to medical management with nasal decongestants and systemic antibiotics. For all cases of orbital cellulitis the im‐ volvement an ophthalmologist is crucial for full assessment of the eye.

It is important to distinguish pre-septal periorbital cellulitis from post-septal (orbital) celluli‐ tis. The orbital septum is an important landmark. It is a continuation of the orbital perios‐ teum that extends to the tarsal plate.

**Figure 4.** Endoscopic view of the left maxillary sinus with a 30 degree telescope showing frank purulence after a max‐

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109

The concept of the orbital septum as a continuation of the periosteum becomes important to un‐ derstand the development of a subperiosteal abscess. The periosteum of the medial orbit lies next to the lamina papyracea; the lamina papyracea is very thin and porous and a potential space can be dissected by an infectious process. The spread of infection from the ethmoid si‐ nuses can lead to phlegmon and abscess between the bone and the orbital periosteum. In rare cases, subperiosteal abscess can also be caused by frontal or maxillary sinusitis [14, 20]. Oxford and McClay suggested guidelines to help determine if surgical treatment is warranted for sub‐ periosteal abscesses. They recommend medical management with frequent re-evaluation of the eye if the following criteria are met: normal vison, pupil, and retina, no ophthalmoplegia,

IOP<20mmHg, proptosis<5mm, and an abscess width of < 4 mm [21].

**Figure 5.** CT scan with contrast, axial, with demonstration of left subperiosteal abscess (enhancing rim).

illary antrostomy was created.

**7.2. Subperiosteal abscess**

Garrett *et al.* examined CT scans of 100 consecutive patients with periorbital cellulitis and noted that children with a dehiscence of the lamina papyracea have a higher incidence of requiring endoscopic sinus surgery to address periorbital infection [18]. Jatana *et al.* reported a rare case of recurrent periorbital sinusitis in a young child which ultimately required en‐ doscopic surgical management; this patient had an abnormal lateralized uncinate and a de‐ hiscence of the lamina papyracea. Congenital anatomical abnormalities may contribute to the pathophysiology of this complication of sinusitis; this highlights the importance of imag‐ ing studies including high-resolution CT and consideration of early surgical intervention particularily in the event of recurrence [19].

**Figure 3.** Endoscopic view with a 0 degree telescope demonstrating scarring of left middle meatus imparing sinus drainage and causing periorbital cellulitis.

**Figure 4.** Endoscopic view of the left maxillary sinus with a 30 degree telescope showing frank purulence after a max‐ illary antrostomy was created.

#### **7.2. Subperiosteal abscess**

cretions in the sinonasal cavity. However, the utility of topical therapies depend on the age

About 60 to 85% of orbital and periorbital infections are attributed to the paranasal sinuses [14]. Periorbital cellulitis is the most frequent complication of sinusitis in the pediatric popu‐ lation. Fortunately, most cases of periorbital cellulitis will respond to medical management with nasal decongestants and systemic antibiotics. For all cases of orbital cellulitis the im‐

It is important to distinguish pre-septal periorbital cellulitis from post-septal (orbital) celluli‐ tis. The orbital septum is an important landmark. It is a continuation of the orbital perios‐

Garrett *et al.* examined CT scans of 100 consecutive patients with periorbital cellulitis and noted that children with a dehiscence of the lamina papyracea have a higher incidence of requiring endoscopic sinus surgery to address periorbital infection [18]. Jatana *et al.* reported a rare case of recurrent periorbital sinusitis in a young child which ultimately required en‐ doscopic surgical management; this patient had an abnormal lateralized uncinate and a de‐ hiscence of the lamina papyracea. Congenital anatomical abnormalities may contribute to the pathophysiology of this complication of sinusitis; this highlights the importance of imag‐ ing studies including high-resolution CT and consideration of early surgical intervention

**Figure 3.** Endoscopic view with a 0 degree telescope demonstrating scarring of left middle meatus imparing sinus

volvement an ophthalmologist is crucial for full assessment of the eye.

and developmental level of each child.

108 Endoscopy

**7.1. Periorbital and orbital cellulitis**

teum that extends to the tarsal plate.

particularily in the event of recurrence [19].

drainage and causing periorbital cellulitis.

**7. Complications of acute sinusitis**

The concept of the orbital septum as a continuation of the periosteum becomes important to un‐ derstand the development of a subperiosteal abscess. The periosteum of the medial orbit lies next to the lamina papyracea; the lamina papyracea is very thin and porous and a potential space can be dissected by an infectious process. The spread of infection from the ethmoid si‐ nuses can lead to phlegmon and abscess between the bone and the orbital periosteum. In rare cases, subperiosteal abscess can also be caused by frontal or maxillary sinusitis [14, 20]. Oxford and McClay suggested guidelines to help determine if surgical treatment is warranted for sub‐ periosteal abscesses. They recommend medical management with frequent re-evaluation of the eye if the following criteria are met: normal vison, pupil, and retina, no ophthalmoplegia, IOP<20mmHg, proptosis<5mm, and an abscess width of < 4 mm [21].

**Figure 5.** CT scan with contrast, axial, with demonstration of left subperiosteal abscess (enhancing rim).

abscesses are true emergencies as they are often associated with acute vision changes secon‐

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111

Meinigitis can be seen in conjunction with other suppurative complications of sinusitis. En‐ hancement of the meninges is seen on CT or MRI if performed with contrast [14]. Meningitis as the sole complication of sinusitis does not always need to be treated with endoscopic surgery. Patients can be started on broad-spectrum antibiotics that cross the blood brain barrier and their clinical progress can be watched closely for 48 hours [23]. Any patient with bacterial meningitis needs to have a close follow-up with audiological testing as significant hearing loss can occur.

Epidural abscess is a collection of purulence external to the dural layer. For children with epidural abscesses due to paranasal sinus infections, there is some controversy as to the ap‐ propriate treatment. Some neurosurgeons feel that if the sinuses are addressed surgically and antibiotics are used, some patients may be able to avoid craniotomy, but this belief is not shared by all in the specialty [24]. Regardless of the exact surgical treatment modality (endoscopic treatment alone or in conjunction with craniotomy), it is important to treat pa‐ tients with a multidisciplinary team that includes infectious disease, otolaryngology, and

Subdural empyema is a collection of purulence between the dura and arachnoid layers. It is considered to be a surgical emergency. Coordination between the neurosurgery and otolar‐ yngology teams is paramount to address the collection via a craniotomy and to address the

**Figure 8.** T1 contrast enhanced MRI showing large subdural empyema in left temporal-parietal region in a 9 year-old

sinus disease that was causative via endoscopic sinus surgery [6, 25].

dary to pressure on the optic nerve or vasospasm of the retinal artery.

**7.4. Meningitis**

**7.5. Epidural abscess**

neurosurgery specialists.

**7.6. Subdural empyema**

with mental status changes and paresis.

**Figure 6.** Left-Endoscopic view of left middle meatus with 0 degree telescope, purulence encountered in the ethmoid sinuses; Right-After endoscopic surgical removal of a portion of the lamina papyracea for drainage of the subperios‐ teal abscess, a blunt probe was placed through the defect. The left periorbita is immediately medial to the tip of the probe.

**Figure 7.** Endoscopic view with a 0 degree telescope of left lamina papyracea and periorbita, the instrument is on the periorbita after removal of a portion of the lamina papyracea. Using endoscopic visualization, an incison through the periorbita (parallel to the medial rectus muscle) could be made if orbital decompression was needed; this is an impor‐ tant consideration in cases of orbital cellulitis/abscess.

The recent trend in treatment for subperiosteal abscesses along the lamina has been to pro‐ ceed with endoscopic treatment with external approaches reserved for treatment failures and abscess that are not accessible via the lamina [22]. Some authors suggest that patients who fail to improve 24 hours after endoscopic drainage could undergo re-imaging to see if they would benefit from an additinal drainage procedure [20]

#### **7.3. Orbital abscess**

When a post-septal infection organizes, an orbital abscess can occur. Orbital abscesses are accessible endoscopically by making an incision in the periorbita. Some orbital abscesses re‐ quire an orbitotomy, which is an external incision to approach the intraorbital contents. En‐ doscopic treatment of the sinuses is important in addition to drainage of the abscess. Orbital abscesses are true emergencies as they are often associated with acute vision changes secon‐ dary to pressure on the optic nerve or vasospasm of the retinal artery.

#### **7.4. Meningitis**

Meinigitis can be seen in conjunction with other suppurative complications of sinusitis. En‐ hancement of the meninges is seen on CT or MRI if performed with contrast [14]. Meningitis as the sole complication of sinusitis does not always need to be treated with endoscopic surgery. Patients can be started on broad-spectrum antibiotics that cross the blood brain barrier and their clinical progress can be watched closely for 48 hours [23]. Any patient with bacterial meningitis needs to have a close follow-up with audiological testing as significant hearing loss can occur.

### **7.5. Epidural abscess**

**Figure 6.** Left-Endoscopic view of left middle meatus with 0 degree telescope, purulence encountered in the ethmoid sinuses; Right-After endoscopic surgical removal of a portion of the lamina papyracea for drainage of the subperios‐ teal abscess, a blunt probe was placed through the defect. The left periorbita is immediately medial to the tip of the

**Figure 7.** Endoscopic view with a 0 degree telescope of left lamina papyracea and periorbita, the instrument is on the periorbita after removal of a portion of the lamina papyracea. Using endoscopic visualization, an incison through the periorbita (parallel to the medial rectus muscle) could be made if orbital decompression was needed; this is an impor‐

The recent trend in treatment for subperiosteal abscesses along the lamina has been to pro‐ ceed with endoscopic treatment with external approaches reserved for treatment failures and abscess that are not accessible via the lamina [22]. Some authors suggest that patients who fail to improve 24 hours after endoscopic drainage could undergo re-imaging to see if

When a post-septal infection organizes, an orbital abscess can occur. Orbital abscesses are accessible endoscopically by making an incision in the periorbita. Some orbital abscesses re‐ quire an orbitotomy, which is an external incision to approach the intraorbital contents. En‐ doscopic treatment of the sinuses is important in addition to drainage of the abscess. Orbital

tant consideration in cases of orbital cellulitis/abscess.

**7.3. Orbital abscess**

they would benefit from an additinal drainage procedure [20]

probe.

110 Endoscopy

Epidural abscess is a collection of purulence external to the dural layer. For children with epidural abscesses due to paranasal sinus infections, there is some controversy as to the ap‐ propriate treatment. Some neurosurgeons feel that if the sinuses are addressed surgically and antibiotics are used, some patients may be able to avoid craniotomy, but this belief is not shared by all in the specialty [24]. Regardless of the exact surgical treatment modality (endoscopic treatment alone or in conjunction with craniotomy), it is important to treat pa‐ tients with a multidisciplinary team that includes infectious disease, otolaryngology, and neurosurgery specialists.

#### **7.6. Subdural empyema**

Subdural empyema is a collection of purulence between the dura and arachnoid layers. It is considered to be a surgical emergency. Coordination between the neurosurgery and otolar‐ yngology teams is paramount to address the collection via a craniotomy and to address the sinus disease that was causative via endoscopic sinus surgery [6, 25].

**Figure 8.** T1 contrast enhanced MRI showing large subdural empyema in left temporal-parietal region in a 9 year-old with mental status changes and paresis.

head [26]. It can also be associated with intracranial abscesses in some cases. The etiology can be infection from sinus disease or due to trauma to the frontal bone resulting in a con‐ duit for spread of infection. Medical management of sinus disease is a component of treat‐ ment, but surgical intervention is paramount. The approach to treat Pott's puffy tumor can be endoscopic with a frontal sinusotomy and anterior ethomidectomy, but a combined ap‐ proach with an external incision may be required depending on the size of the subperiosteal abscess and whether or not there are associated intracranial complications. Following surgi‐ cal treatment, patients will require prolonged courses of IV antibiotics until the osteomyeli‐

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113

**Figure 11.** Axial CT showing left frontal sinus opacification and connection to scalp, consistent with Pott's Puffy. Ap‐

proximately 80 mL of purulence was drained from the scalp abscess.

**Figure 12.** Endoscopic view of the left frontal sinus with a 70 degree telescope.

tis has resolved [27].

**Figure 9.** Endoscopic view of the right frontal recess using a 70 degree telescope, purulence was drained from the frontal sinus after craniotomy in this 9 year-old patient.

#### **7.7. Intracerebral abcess**

Cerebritis can be considered a pre-cursor of actual abscess within the brain parynchema. Cerebritis can be suggested on contrast-enhanced CT and also on MRI with ill-defined en‐ hancement. Actual abscesses within the brain are best diagnosed with MRI and are at times difficult to distinguish from cystic tumors [14]. Intracerebral abscesses are most frequent in the frontal lobe adjacent to the frontal sinus [10]. In general, neurosurgical drainage of the intracranial abscess and endoscopic sinus surgery for any associated intranasal pathology are of the utmost importance.

**Figure 10.** MRI with contrast, showing enhancing abscess within right frontal lobe.

#### **7.8. Pott's Puffy/osteomyelitis**

Pott's puffy "tumor" is an infectious complication of sinusitis involving frontal bone osteo‐ myelitis with an associated frontal subperiosteal abscess that creates swelling of the fore‐ head [26]. It can also be associated with intracranial abscesses in some cases. The etiology can be infection from sinus disease or due to trauma to the frontal bone resulting in a con‐ duit for spread of infection. Medical management of sinus disease is a component of treat‐ ment, but surgical intervention is paramount. The approach to treat Pott's puffy tumor can be endoscopic with a frontal sinusotomy and anterior ethomidectomy, but a combined ap‐ proach with an external incision may be required depending on the size of the subperiosteal abscess and whether or not there are associated intracranial complications. Following surgi‐ cal treatment, patients will require prolonged courses of IV antibiotics until the osteomyeli‐ tis has resolved [27].

**Figure 11.** Axial CT showing left frontal sinus opacification and connection to scalp, consistent with Pott's Puffy. Ap‐ proximately 80 mL of purulence was drained from the scalp abscess.

**Figure 12.** Endoscopic view of the left frontal sinus with a 70 degree telescope.

**Figure 9.** Endoscopic view of the right frontal recess using a 70 degree telescope, purulence was drained from the

Cerebritis can be considered a pre-cursor of actual abscess within the brain parynchema. Cerebritis can be suggested on contrast-enhanced CT and also on MRI with ill-defined en‐ hancement. Actual abscesses within the brain are best diagnosed with MRI and are at times difficult to distinguish from cystic tumors [14]. Intracerebral abscesses are most frequent in the frontal lobe adjacent to the frontal sinus [10]. In general, neurosurgical drainage of the intracranial abscess and endoscopic sinus surgery for any associated intranasal pathology

Pott's puffy "tumor" is an infectious complication of sinusitis involving frontal bone osteo‐ myelitis with an associated frontal subperiosteal abscess that creates swelling of the fore‐

frontal sinus after craniotomy in this 9 year-old patient.

**Figure 10.** MRI with contrast, showing enhancing abscess within right frontal lobe.

**7.7. Intracerebral abcess**

112 Endoscopy

are of the utmost importance.

**7.8. Pott's Puffy/osteomyelitis**

### **7.9. Cavernous sinus thrombosis**

Cavernous sinus thrombosis can occur due to the spread of infection from the middle third of the face or from the sinuses and orbit due to the valveless venous system in the anatomi‐ cal region [28]. Emergent drainage of any paranasal sinus or orbital infection is important in conjunction with intravenous antibiotics. Systemic anticoagulation is considered in all of these cases. Despite aggressive treatment, cavernous sinus thrombosis remains a life-threat‐ ening illness (in addition to causing to cranial neuropathy and blindness) that requires mul‐ tidisciplinary care in an intensive care unit setting.

agement until they show clinical improvement. These patients generally need multidisciplinary involvement including the surgical teams of neurosurgery, otolaryngol‐ ogy and ophthalmology as well as an infectious disease specialist. Serial opthalmological examinations are important to optimize visual outcomes when the orbit is involved. Giv‐ en the consequences of persistent or recurrent infection, the threshold for repeat imaging and possible return to the operating room must remain low. Antibiotic therapy can be tailored to the particular culture results when available. Adjunctive therapy such as topi‐ cal and systemic decongestants and nasal saline spray or irrigation are also of impor‐

Role of Endoscopic Sinus Surgery in Pediatric Acute Complicated Sinusitis

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115

Primary outpatient management of complicated acute sinusitis is not the standard of care. Once patients are stabilized clinically, they can often be treated with outpatient an‐ tibiotic regimens via PICC lines or in some cases be transitioned to an oral regimen. From the otolaryngologist's perspective, some children who have endoscopic sinus sur‐ gery may need to return to the operating room for debridement during the healing proc‐ ess. During the early years of endoscopic sinus surgery, taking children back to the operating room two to three weeks after surgery for debridement was the standard of care [31]. However, after further evaluation, this approach was found to have no benefit in terms of nasal obstruction, drainage or cough [32]. A secondary procedure in the op‐ erating room should be considered for select patients depending on how well they are able to irrigate as well as how easily they tolerate endoscopic exam and gentle debride‐ ment in the clinic. The threshold for return to the operating room for patients who un‐ derwent major dissections should be lower than for those who had more limited procedures [33]. Parents must be informed at the time of the initial surgery that multiple surgical procedures may be required. Surveillance of scar tissue formation, which is more common in the setting of acute infection, can be performed endoscopically in the office. If there is concern that the sinuses are not draining properly, revision surgery

should be performed to prevent return of the previous complication.

ma or inflammatory tissues that interfere with endoscopic visualization.

Although intranasal approaches are frequently the preferred route for accessing the para‐ nasal sinuses and the medial orbit, patients and their families should be counseled that ex‐ ternal approaches to the anterior ethmoid region may be required. The Lynch approach leaves a scar that courses from the medial brow along the side of the nose but may be re‐ quired in cases where the medial orbit cannot be accessed endoscopically due to severe ede‐

**10. Open surgical approaches**

**10.1. Lynch incision**

tance during this period.

**9.2. Outpatient**

### **8. Complications of endoscopic sinus surgery**

Major complications after endoscopic sinus surgery include CSF leak, orbital injury and hemorrhage. A recent retrospective study by Ramakrishnan *et al.* looked at overall rates of major complications after endoscopic sinus surgery. The overall rate of major complications across all age groups was 1%. This was divided among patients with CSF leak (0.17%), pa‐ tients with orbital injuries (0.07%), and patients with significant hemorrhage that required blood transfusion (0.76%). This data represents significant improvement from previous ret‐ rospective analyses. When the complications were stratified by age, they found that CSF leak was less likely to occur in children, but orbital injury was more likely in the pediatric population. This likely stems from smaller maxillary sinuses and lower orbital floors in young children.

Concerns have been raised that sinus surgery in children could affect facial growth. An ani‐ mal study looking at facial growth in piglets that underwent endoscopic sinus surgery re‐ vealed decreased facial growth on the operative side. This same study investigated the types of bone that were removed from pediatric patients who underwent endoscopic sinus sur‐ gery and noted that children less than 9 years old had immature bone in contrast to children over 9 years old and older who had more mature bone in their specimens [29].

A quantitative study in pediatric patients was performed by Senior *et al.* in order to evaluate facial growth using CT scan images and volumetric analysis. Their study looked at patients who underwent sinus surgery due to orbital cellulitis and abscess and re-evaluated the pa‐ tients 4 to 10 years later. There was no statistically significant difference in sinus volume from the operated side to the non-operated side. However, a small difference in orbital vol‐ ume was noted from the operated side to the non-operated side. Overall, they concluded that sinus surgery in children has minimal impact on sinus and facial growth [30].

### **9. Post-operative management**

#### **9.1. Inpatient**

Patients with acute complicated sinusitis will require close monitoring after surgical in‐ tervention. Patients with intracranial involvement may require intensive care unit man‐ agement until they show clinical improvement. These patients generally need multidisciplinary involvement including the surgical teams of neurosurgery, otolaryngol‐ ogy and ophthalmology as well as an infectious disease specialist. Serial opthalmological examinations are important to optimize visual outcomes when the orbit is involved. Giv‐ en the consequences of persistent or recurrent infection, the threshold for repeat imaging and possible return to the operating room must remain low. Antibiotic therapy can be tailored to the particular culture results when available. Adjunctive therapy such as topi‐ cal and systemic decongestants and nasal saline spray or irrigation are also of impor‐ tance during this period.

#### **9.2. Outpatient**

**7.9. Cavernous sinus thrombosis**

114 Endoscopy

young children.

**9.1. Inpatient**

**9. Post-operative management**

tidisciplinary care in an intensive care unit setting.

**8. Complications of endoscopic sinus surgery**

Cavernous sinus thrombosis can occur due to the spread of infection from the middle third of the face or from the sinuses and orbit due to the valveless venous system in the anatomi‐ cal region [28]. Emergent drainage of any paranasal sinus or orbital infection is important in conjunction with intravenous antibiotics. Systemic anticoagulation is considered in all of these cases. Despite aggressive treatment, cavernous sinus thrombosis remains a life-threat‐ ening illness (in addition to causing to cranial neuropathy and blindness) that requires mul‐

Major complications after endoscopic sinus surgery include CSF leak, orbital injury and hemorrhage. A recent retrospective study by Ramakrishnan *et al.* looked at overall rates of major complications after endoscopic sinus surgery. The overall rate of major complications across all age groups was 1%. This was divided among patients with CSF leak (0.17%), pa‐ tients with orbital injuries (0.07%), and patients with significant hemorrhage that required blood transfusion (0.76%). This data represents significant improvement from previous ret‐ rospective analyses. When the complications were stratified by age, they found that CSF leak was less likely to occur in children, but orbital injury was more likely in the pediatric population. This likely stems from smaller maxillary sinuses and lower orbital floors in

Concerns have been raised that sinus surgery in children could affect facial growth. An ani‐ mal study looking at facial growth in piglets that underwent endoscopic sinus surgery re‐ vealed decreased facial growth on the operative side. This same study investigated the types of bone that were removed from pediatric patients who underwent endoscopic sinus sur‐ gery and noted that children less than 9 years old had immature bone in contrast to children

A quantitative study in pediatric patients was performed by Senior *et al.* in order to evaluate facial growth using CT scan images and volumetric analysis. Their study looked at patients who underwent sinus surgery due to orbital cellulitis and abscess and re-evaluated the pa‐ tients 4 to 10 years later. There was no statistically significant difference in sinus volume from the operated side to the non-operated side. However, a small difference in orbital vol‐ ume was noted from the operated side to the non-operated side. Overall, they concluded

Patients with acute complicated sinusitis will require close monitoring after surgical in‐ tervention. Patients with intracranial involvement may require intensive care unit man‐

over 9 years old and older who had more mature bone in their specimens [29].

that sinus surgery in children has minimal impact on sinus and facial growth [30].

Primary outpatient management of complicated acute sinusitis is not the standard of care. Once patients are stabilized clinically, they can often be treated with outpatient an‐ tibiotic regimens via PICC lines or in some cases be transitioned to an oral regimen. From the otolaryngologist's perspective, some children who have endoscopic sinus sur‐ gery may need to return to the operating room for debridement during the healing proc‐ ess. During the early years of endoscopic sinus surgery, taking children back to the operating room two to three weeks after surgery for debridement was the standard of care [31]. However, after further evaluation, this approach was found to have no benefit in terms of nasal obstruction, drainage or cough [32]. A secondary procedure in the op‐ erating room should be considered for select patients depending on how well they are able to irrigate as well as how easily they tolerate endoscopic exam and gentle debride‐ ment in the clinic. The threshold for return to the operating room for patients who un‐ derwent major dissections should be lower than for those who had more limited procedures [33]. Parents must be informed at the time of the initial surgery that multiple surgical procedures may be required. Surveillance of scar tissue formation, which is more common in the setting of acute infection, can be performed endoscopically in the office. If there is concern that the sinuses are not draining properly, revision surgery should be performed to prevent return of the previous complication.

### **10. Open surgical approaches**

#### **10.1. Lynch incision**

Although intranasal approaches are frequently the preferred route for accessing the para‐ nasal sinuses and the medial orbit, patients and their families should be counseled that ex‐ ternal approaches to the anterior ethmoid region may be required. The Lynch approach leaves a scar that courses from the medial brow along the side of the nose but may be re‐ quired in cases where the medial orbit cannot be accessed endoscopically due to severe ede‐ ma or inflammatory tissues that interfere with endoscopic visualization.

### **10.2. Trephination**

Trephination is another adjunctive external approach that is particularly helpful to access the frontal sinus. It requires a small external incision but can help minimize operating room time in patients that are clinically unstable. Additionally, a case series reported the use of mini-trephination of the frontal sinus with drain placement as a possible adjunct for patients with sinusitis complicated with intracranial infection [34]. An endoscope can also be used for improved visualization of the frontal sinus through the trephination and has been described by Jatana *et al.* to assist in repair of a subclinical CSF leak from an isolated posterior table frontal sinus fracture that caused recurrent meningitis in a pedia‐ tric patient [35].

**11. Conclusion**

**Author details**

Timothy P. McEvoy1

**References**

272-5.

Hospital, Columbus, Ohio, USA

Ohio State University, Columbus, Ohio, USA

1985/09/01., 111(9), 576-82.

(1985). Epub 1985/10/01., 111(10), 643-9.

(2011). Epub 2011/06/30., 25(1), 30-5.

cares for patients with complications of sinusitis.

Endoscopic surgical techniques are an important component of treatment for acute compli‐ cated sinusitis in the pediatric population. Given the diverse nature or presenting signs and symptoms, a high index of suspicion for complications of sinusitis must be maintained for patients presenting with complaints previously described. Using endoscopic approaches to the sinuses, the otolaryngologist is an important member of the multidisciplinary team that

Role of Endoscopic Sinus Surgery in Pediatric Acute Complicated Sinusitis

http://dx.doi.org/10.5772/52551

117

, Charles A. Elmaraghy1,2 and Kris R. Jatana1,2

1 Department of Pediatric Otolaryngology-Head and Neck Surgery, Nationwide Children's

2 Department of Otolaryngology-Head and Neck Surgery, Wexner Medical Center at The

[1] Kennedy DW.Functional endoscopic sinus surgery. Technique. Arch Otolaryngol.

[2] Kennedy DW, Zinreich SJ, Rosenbaum AE, Johns ME.Functional endoscopic sinus surgery. Theory and diagnostic evaluation. Arch Otolaryngol. (1985). Epub

[3] Gross CW, Gurucharri MJ, Lazar RH, Long TE.Functional endonasal sinus surgery (FESS) in the pediatric age group. The Laryngoscope(1989). Epub 1989/03/01., 99(3),

[5] Adibelli, Z. H., Songu, M., & Adibelli, H. Paranasal sinus development in children: A magnetic resonance imaging analysis. American journal of rhinology & allergy.

[6] Yucel, O. T., & Ogretmenoglu, O. Subdural empyema and blindness due to caver‐ nous sinus thrombosis in acute frontal sinusitis. International journal of pediatric

[4] al, R., & , . Embryology and Anatomy of the Paranasal Sinuses. 4th ed(2003).

otorhinolaryngology(1998). Epub 1999/04/06., 121 EOF-5 EOF.

\*Address all correspondence to: Kris.Jatana@nationwidechildrens.org

**Figure 13.** Right frontal sinus trephination performed in conjuction with an endoscopic approach and a drain for irri‐ gation was placed into the right frontal sinus.

#### **10.3. Transcaruncular**

Another external approach that does not have the drawback of visible scarring is the trans‐ caruncular approach. This approach is performed by making a transconjunctival incision just lateral or medial to the lacrimal caruncle and then dissecting to the anterior medial orbi‐ tal wall. Dissection then continues by elevating the periorbita from the lamina until the ab‐ scess is accessed. This approach can be used in conjunction with endoscopic drainage of a subperiosteal abscess to ensure that the entire cavity is adequately drained and reduce the risk of recurrence [36].

### **11. Conclusion**

**10.2. Trephination**

116 Endoscopy

tric patient [35].

gation was placed into the right frontal sinus.

**10.3. Transcaruncular**

risk of recurrence [36].

Trephination is another adjunctive external approach that is particularly helpful to access the frontal sinus. It requires a small external incision but can help minimize operating room time in patients that are clinically unstable. Additionally, a case series reported the use of mini-trephination of the frontal sinus with drain placement as a possible adjunct for patients with sinusitis complicated with intracranial infection [34]. An endoscope can also be used for improved visualization of the frontal sinus through the trephination and has been described by Jatana *et al.* to assist in repair of a subclinical CSF leak from an isolated posterior table frontal sinus fracture that caused recurrent meningitis in a pedia‐

**Figure 13.** Right frontal sinus trephination performed in conjuction with an endoscopic approach and a drain for irri‐

Another external approach that does not have the drawback of visible scarring is the trans‐ caruncular approach. This approach is performed by making a transconjunctival incision just lateral or medial to the lacrimal caruncle and then dissecting to the anterior medial orbi‐ tal wall. Dissection then continues by elevating the periorbita from the lamina until the ab‐ scess is accessed. This approach can be used in conjunction with endoscopic drainage of a subperiosteal abscess to ensure that the entire cavity is adequately drained and reduce the Endoscopic surgical techniques are an important component of treatment for acute compli‐ cated sinusitis in the pediatric population. Given the diverse nature or presenting signs and symptoms, a high index of suspicion for complications of sinusitis must be maintained for patients presenting with complaints previously described. Using endoscopic approaches to the sinuses, the otolaryngologist is an important member of the multidisciplinary team that cares for patients with complications of sinusitis.

### **Author details**

Timothy P. McEvoy1 , Charles A. Elmaraghy1,2 and Kris R. Jatana1,2

\*Address all correspondence to: Kris.Jatana@nationwidechildrens.org

1 Department of Pediatric Otolaryngology-Head and Neck Surgery, Nationwide Children's Hospital, Columbus, Ohio, USA

2 Department of Otolaryngology-Head and Neck Surgery, Wexner Medical Center at The Ohio State University, Columbus, Ohio, USA

### **References**


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[20] Noordzij JP, Harrison SE, Mason JC, Hashisaki GT, Reibel JF, Gross CW.Pitfalls in the endoscopic drainage of subperiosteal orbital abscesses secondary to sinusitis.

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**Chapter 8**

**Endoscopy -**

Saul Frenkiel

**1. Introduction**

scopic approach.

**An Advancement in Sinus**

Rickul Varshney, Faisal Zawawi, Marc A Tewfik and

Skull base and sinus surgery has evolved dramatically throughout the past century. It is not long ago that the maxillary sinus would principally be reached via an anterior ap‐ proach through the gingivobuccal sulcus of the oral cavity. The earliest days of endos‐ copy date back to the early 1900s, when Hirschmann used a modified cystoscope to examine the sinuses. Thereafter, modern endoscopy has seen advances not only in the types of endoscopes available, but also the types of interventions amenable to the endo‐

However, even in this modern era of refined endoscopic instrumentation and technique, opinion remains split regarding the optimal approach to certain areas of the skull base. For example, areas such as the anterior cranial fossa and the infratemporal fossa are of‐ ten approached through external transcutaneous approaches despite the development of

The current chapter aims to provide a complete comparison of endoscopic versus open approaches of routinely performed sinus and skull base surgical procedures. It will also emphasize the advantages of endoscopy versus traditional approaches for sinus and skull base surgery, including management of tumors, infectious processes, congenital

and reproduction in any medium, provided the original work is properly cited.

© 2013 Varshney et al.; licensee InTech. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

© 2013 The Author(s). Licensee InTech. This chapter is distributed under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution,

Additional information is available at the end of the chapter

adequate and safe transnasal endoscopic pathway.

anomalies and traumatic injuries.

**and Skull Base Surgery**

http://dx.doi.org/10.5772/52749


**Chapter 8**
