**Meet the editor**

Dr. Ahmed Kaseb is an Associate Professor and program director of Hepatocellular Carcinoma (HCC) at The University of Texas MD Anderson Cancer Center, Houston, Texas, USA. Dr. Kaseb received his medical degree from Cairo University, and worked at University of Michigan, and Wayne State University and Henry Ford Hospital, in Detroit, Michigan. Dr. Kaseb has contributed greatly to

the understanding of HCC interdisciplinary therapies and molecular staging, and received funding for several projects and clinical trials. Dr. Kaseb serves as an Editor and reviewer for several international journals, and has received several national and international awards throughout his career. Dr. Kaseb has authored and co-authored over 50 papers and book chapters.

Contents

**Preface VII**

Chapter 1 **Role of Alleles and Genotypes of Polymorphisms of IL-18 (-607**

**-308 A/G) and HLA-G Genes in the Susceptibility of**

Emad H. Asham, Howard Mansour and Mark Ghobrial

Hojjat Ahmadzadehfar, Amir Sabet and Hans Jürgen Biersack

Chapter 2 **Liver Transplantation for Hepatocellular Carcinoma 21**

Chapter 3 **Radioembolization for the Treatment of Unresectable**

Chapter 4 **Image-Guided Therapies for Hepatocellular Carcinoma in Hepatocelluar Carcinoma — Future Outlook 63** Bruno C. Odisio, Ravi Murthy and Michael J. Wallace

Xin-yu Huang, Qi Zheng and Zhou Yuan

Chapter 7 **Early Chronic Inflammation and Subsequent Somatic**

**in Future 97**

**Diseases 113**

Sanchari and Shampa Ghosh

Chapter 5 **Neoadjuvant Chemotherapy for Hepatocellular Carcinoma 81**

Chapter 6 **Targets and Approaches to Control Hepatocellular Carcinoma**

Mukherjee Biswajit, Hossain Chowdhury Mobaswar , Bhattacharya

**Mutations Shift Phospho-Smad3 Signaling from Tumor-Suppression to Fibro-Carcinogenesis in Human Chronic Liver**

Miki Murata, Katsunori Yoshida and Koichi Matsuzaki

**Hepatocellular Carcinoma 1**

**Hepatocellular Carcinoma 41**

Eduardo Antonio Donadi

**C/A; and -137 C/G), IFN-γ (+874 A/T) and TNF-α (-238 A/G and**

Andreza Correa Teixeira, Ana de Lourdes Candolo Martinelli and
