**Acknowledgements**

The work on FMDV discussed in this chapter was supported by grants BIO2008-04487-C03-01, AGL2011-24509 and BIO2011-24351 and by the ICTS program from the Spanish Ministry of Science and Innovation. We also thank Francisco Mateos, Nuria de la Losa and Lourdes Peña for their assistance in mice experiments. We are also grateful to Encarna Martínez-Salas for reagents and helpful discussion.

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