**Meet the editor**

Jindong Chen, Ph.D., Research Associate Professor, Laboratory Co-director, AACR active member, Kidney Cancer Laboratory, Department of Urology, University of Rochester Medical Center, New York, USA. Upon graduation from Laboratory of Cancer Genetics, Department of Molecular Medicine, Karolinska Institute, Sweden, he has been working on kidney cancer since

2000. Upon graduation, he has served as Postdoctoral Fellow, Research Scientist at Van Andel Research Institute, USA; Senior Scientist at National Cancer Centre Singapore. He identified two kidney cancer-related genes, NORE1 and LSAMP by positional cloning strategy, and was awarded in 94th AACR annual meeting. In addition, he was also involved in cloning of another kidney cancer-related gene HRPT2. Afterward, he has successfully developed a few FLCN (BHD) and HRPT2 conditional knockout mouse models and was again awarded in the 100th AACR annual Meeting for generating the first renal tumor-developing FLCN knockout mouse model.

Contents

**Preface VII**

Chapter 1 **Genetics of Renal Tumors 3**

Kazunari Yoshida

**Section 1 Molecular Biology of Renal Tumor 1**

Ryoiti Kiyama, Yun Zhu and Tei-ichiro Aoyagi

Chapter 3 **Imagen Thecniques in Renal-Cell Carcinoma 45**

**Section 2 Management of Localized Renal Tumor 69**

Chapter 4 **Renal Cell Carcinoma: Clinical Surgery 71**

**Carcinoma 4 to 7 cm in Size 87**

H. Zielinski, T. Syrylo and S. Szmigielski

**Carcinoma 109** Akihiro Tojo

Chapter 2 **Signaling Pathways and Biomarkers in Renal Tumors 31**

Fernandez, U. Anido, J. Afonso and L. A. Aparicio

Carolin Eva Hach, Stefan Siemer and Stephan Buse

Chapter 5 **Nephron-Sparing Surgery for the Treatment of Renal Cell**

Ambrosi Pertia, Laurent Managadze and Archil Chkhotua

Chapter 6 **Renal Artery Embolization in Treatment of Renal Cancer with Emphasis on Response of Immune System 95**

Chapter 7 **Paraneoplastic Glomerulopathy Associated with Renal Cell**

Tetsuo Fujita, Masatsugu Iwamura, Kazumasa Matsumoto and

L. León, M. Ramos, M. Lázaro, S. Vázquez, M. C. Areses, O.
