**Meet the editors**

Dr. Bassam H. Mahboub is currently head of Department of pulmonary medicine, allergy and sleep medicine, Rashid Hospital, Dubai, and Assistant professor of medicine and chest disease, University of Sharjah, UAE. His main area of research and clinical interest includes asthma, respiratory allergy and COPD. Dr. Bassam completed his American Board of Internal Medicine, Pulmonology, American Board

Allergy Clinical Immunology. Dr. Bassam got the fellowship of Royal college of physicians and Royal college Allergy and Clinical Immunology, Canada. Before he was assistant medical director and consultant and head of division of allergy/ immunology and respiratory medicine, Al Baraha Hospital, Ministry of Health, Dubai. Dr Bassam is holding the position of Head and vice chairman of various medical professional societies in UAE and GCC countries. Dr. Bassam has the credit of supervising graduates, postgraduates and doctoral students focusing on research in the field of respiratory medicine and allergy and immunology. He has authored many peer reviewed articles including original research, chapters published in international books and journals. He is presently also involved in numerous research projects undergoing in Gulf countries and the academic activities for the specialist doctors in UAE.

Dr. Mayank G. Vats is Senior Specialist in the Department of Pulmonary Medicine and Allergy and Sleep Medicine, Rashid Hospital, Dubai. His main area of research and clinical interest includes asthma, respiratory allergy, COPD and sleep medicine. Dr. Vats completed his postgraduate education (MD) in pulmonary medicine, then he did DNB in respiratory medicine and DNB in critical care medicine

from the prestigious Escorts Heart Institute in New Delhi, India. After that he served as consultant pulmonologist, intensivist and sleep physician at Escorts Heart Institute and Apollo Hospital, New Delhi, India, for more than 3 years. Dr. Vats also got extensive training in sleep medicine by American Academy of Sleep Medicine at LDS Hospital, Salt Lake City, UTAH, USA. Dr. Vats got the membership of Royal college of physicians and surgeons of Glasgow, UK and was elected as fellow of American College of Physicians (FACP) and fellow of American College of Chest Physicians (FCCP). He is the European Diplomat in Respiratory Medicine. Previously he provided his services as Specialist (A) in the Department of medicine and chest disease, Al Qassimi Hspital, Sharjah, UAE. Dr. Vats is member in good standing of various medical professional societies, ERS, ACCP, AASM, APSR, ISCCM, to name a few. He has authored many peer reviewed articles including original research, case reports, review articles and chapters published in international books and journals. He is presently also involved in many research projects in Gulf countries and the academic activities for the specialist doctors in UAE.

Contents

**Preface IX**

**Human Host 3** Beatrice Saviola

**Tuberculosis 57**

**Infection in Humans 19** Zeev Theodor Handzel

**Section 1 Pathophysiology and Immunogenesis of Tuberculosis 1**

Chapter 1 **Mycobacterium tuberculosis Adaptation to Survival in a**

Chapter 2 **The Immune Response to Mycobacterium tuberculosis**

Matthias Stehr, Ayssar A. Elamin and Mahavir Singh

Armando Acosta, Yamile Lopez, Norazmi Mohd Nor, Rogelio Hernández Pando, Nadine Alvarez, Maria Elena Sarmiento and

**Factor Alpha (TNF–α) Gene Polymorphisms in TB Occurrence**

Márcia Quinhones Pires Lopes, Raquel Lima de Figueiredo Teixeira, Antonio Basilio de Miranda, Rafael Santos Pinto, Lizânia Borges Spinassé, Fernanda Carvalho Queiroz Mello, José Roberto Lapa e

Raquel Lima de Figueiredo Teixeira, Márcia Quinhones Pires Lopes,

Chapter 5 **Influence of the Interferon–Gamma (IFN–γ) and Tumor Necrosis**

Silva, Philip Noel Suffys and Adalberto Rezende Santos

Chapter 6 **Tuberculosis Pharmacogenetics: State of The Art 105**

Philip Noel Suffys and Adalberto Rezende Santos

Chapter 3 **Lipid Inclusions in Mycobacterial Infections 31**

Chapter 4 **The Role of Antibodies in the Defense Against**

Aharona Glatman-Freedman

**and Clinical Spectrum 79**
